Parkinson’s disease and Alzheimer’s disease: a Mendelian randomization study

BMC Medical Genetics

Table 1 Characteristics of 7 SNCA genetic variants reported in PD GWASs

SNP	Chr:BP^a	Reported year	Source	Reported ancestry	LD (r²)^b	Function class	EA	NEA	EAF	OR (95% CI)	P value
rs356182	4: 90626111	2017	Chang D [20]	European	1	Intron variant	G	A	0.404	1.33 (1.30–1.36)	5.21E-123
rs356219	4:89716450	2012	Lill CM [47]	Caucasian	0.76	Intron variant	G	A	0.41	1.29 (1.25–1.33)	6.00E-65
rs356220	4:89720189	2014	Hill-Burns EM [48]	European	0.51	Intron variant	T	C	0.364	1.38 (1.24–1.52)	3.00E-11
rs2736990	4:89757390	2010	Edwards DL [49]	Caucasian	0.48	Intron variant	G	A	0.52	1.30 (1.18–1.43)	6.74E-8
rs8180209	4:89723303	2017	Foo JN [50]	Han Chinese	NA^c	Intron variant	A	G	0.07	0.41 (NA^d)	1.02E-32
rs11931074	4:89718364	2009	Satake W [51]	Japanese	NA^c	Intron variant	G	T	0.36	1.37 (1.27–1.48)	7.35E-17
rs6532194	4:89859751	2012	Lill CM [47]	Asian	NA^c	Intergenic variant	T	C	0.40	1.29 (1.20–1.39)	4.91E-11

^aChr:BP, Chromosome:Position
^brepresent the r² value of linkage disequilibrium (LD) between the selected genetic variant and the tagged mutation rs356182. The range of r² is 0–1, the greater the value of r², the stronger the linkage disequilibrium
^cThe genetic variants were not reported in European (or Caucasian) populations
^dThe 95% CI of OR was not available

ISSN: 1471-2350