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Table 1 Characteristics of 7 SNCA genetic variants reported in PD GWASs

From: Parkinson’s disease and Alzheimer’s disease: a Mendelian randomization study

SNP Chr:BPa Reported year Source Reported ancestry LD (r2)b Function class EA NEA EAF OR (95% CI) P value
rs356182 4: 90626111 2017 Chang D [20] European 1 Intron variant G A 0.404 1.33 (1.30–1.36) 5.21E-123
rs356219 4:89716450 2012 Lill CM [47] Caucasian 0.76 Intron variant G A 0.41 1.29 (1.25–1.33) 6.00E-65
rs356220 4:89720189 2014 Hill-Burns EM [48] European 0.51 Intron variant T C 0.364 1.38 (1.24–1.52) 3.00E-11
rs2736990 4:89757390 2010 Edwards DL [49] Caucasian 0.48 Intron variant G A 0.52 1.30 (1.18–1.43) 6.74E-8
rs8180209 4:89723303 2017 Foo JN [50] Han Chinese NAc Intron variant A G 0.07 0.41 (NAd) 1.02E-32
rs11931074 4:89718364 2009 Satake W [51] Japanese NAc Intron variant G T 0.36 1.37 (1.27–1.48) 7.35E-17
rs6532194 4:89859751 2012 Lill CM [47] Asian NAc Intergenic variant T C 0.40 1.29 (1.20–1.39) 4.91E-11
  1. aChr:BP, Chromosome:Position
  2. brepresent the r2 value of linkage disequilibrium (LD) between the selected genetic variant and the tagged mutation rs356182. The range of r2 is 0–1, the greater the value of r2, the stronger the linkage disequilibrium
  3. cThe genetic variants were not reported in European (or Caucasian) populations
  4. dThe 95% CI of OR was not available