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Fig. 1 | BMC Medical Genetics

Fig. 1

From: De novo variant of TRRAP in a patient with very early onset psychosis in the context of non-verbal learning disability and obsessive-compulsive disorder: a case report

Fig. 1

Modeling of the Arg1986 residue in TRRAP. a The yeast homologue of TRRAP, Tra1(5OEJ), was chosen as a template to model TRRAP, as Tra1 is matched at position Arg2004 to Arg1986 in human TRRAP. The variant is removed from the kinase domain (noted in blue), and close to the central cavity. b Wild-type Arg1986. c Arg1986Gln. This substitution may reduce the side chain volume and decrease the binding between TRRAP and DNA

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BMC Medical Genetics

ISSN: 1471-2350

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