The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women

Mondockova, Vladimira; Adamkovicova, Maria; Lukacova, Martina; Grosskopf, Birgit; Babosova, Ramona; Galbavy, Drahomir; Martiniakova, Monika; Omelka, Radoslav

doi:10.1186/s12881-018-0684-8

Table 6 BMD changes after hormone therapy in relation to the rs9340799 and rs2234693 genotypes

From: The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women

Genotypes	Skeletal site	BMD before treatment	BMD after treatment	BMD difference after treatment	GLM Sig. (P value)	PC Sig. (P value)
rs9340799:A > G genotypes
GG	FN T-score	−2.108 ± 0.106	−1.500 ± 0.082	0.608 ± 0.090	0.001
GG	FN BMD	0.605 ± 0.013	0.678 ± 0.010	0.073 ± 0.011 (+ 12.6%)	0.001
AG	FN T-score	−2.138 ± 0.063	−1.738 ± 0.049	0.400 ± 0.061	0.001
AG	FN BMD	0.601 ± 0.008	0.649 ± 0.006	0.048 ± 0.007 (+ 8.4%)	0.001
AA	FN T-score	−2.141 ± 0.082	−1.991 ± 0.063	0.150 ± 0.066	0.035
AA	FN BMD	0.601 ± 0.010	0.619 ± 0.008	0.018 ± 0.008 (+ 3.4%)	0.035
GG-AG	FN T-score			0.134 ± 0.952	0.042 for FN T-score and FN BMD	NS
GG-AG	FN BMD			0.016 ± 0.011		NS
GG-AA	FN T-score			0.262 ± 0.103		0.035
GG-AA	FN BMD			0.031 ± 0.012		0.035
AG-AA	FN T-score			0.128 ± 0.795		NS
AG-AA	FN BMD			0.015 ± 0.010		NS
GG	LS T-score	−2.877 ± 0.109	−1.823 ± 0.094	1.054 ± 0.053	0.001
GG	LS BMD	0.675 ± 0.012	0.788 ± 0.010	0.113 ± 0.006 (+ 16.9%)	0.001
AG	LS T-score	−2.843 ± 0.064	− 2.105 ± 0.056	0.738 ± 0.073	0.001
AG	LS BMD	0.679 ± 0.007	0.758 ± 0.006	0.079 ± 0.008 (+ 11.9%)	0.001
AA	LS T-score	−2.932 ± 0.083	− 2.459 ± 0.073	0.473 ± 0.125	0.001
AA	LS BMD	0.669 ± 0.009	0.720 ± 0.008	0.051 ± 0.013 (+ 8.3%)	0.001
GG-AG	LS T-score			0.124 ± 0.092	0.002 for FN T-score and FN BMD	NS
GG-AG	LS BMD			0.013 ± 0.010		NS
GG-AA	LS T-score			0.345 ± 0.100		0.003
GG-AA	LS BMD			0.037 ± 0.011		0.003
AG-AA	LS T-score			0.221 ± 0.077		0.014
AG-AA	LS BMD			0.024 ± 0.008		0.014
rs2234693:T > C genotypes
CC	FN T-score	−2.124 ± 0.093	−1.518 ± 0.072	0.606 ± 0.081	0.001
CC	FN BMD	0.603 ± 0.011	0.676 ± 0.09	0.073 ± 0.010 (+ 12.6%)	0.001
TC	FN T-score	−2.139 ± 0.064	−1.772 ± 0.049	0.367 ± 0.058	0.001
TC	FN BMD	0.601 ± 0.008	0.645 ± 0.006	0.044 ± 0.007 (+ 7.7%)	0.001
TT	FN T-score	−2.132 ± 0.088	−2.000 ± 0.068	0.132 ± 0.077	NS
TT	FN BMD	0.602 ± 0.011	0.618 ± 0.008	0.016 ± 0.009 (+ 3.0%)	NS
CC-TC	FN T-score				NS for FN T-score and FN BMD
CC-TC	FN BMD
CC-TT	FN T-score
CC-TT	FN BMD
TC-TT	FN T-score
TC-TT	FN BMD
CC	LS T-score	−2.894 ± 0.095	−1.818 ± 0.079	1.077 ± 0.067	0.001
CC	LS BMD	0.673 ± 0.010	0.789 ± 0.008	0.115 ± 0.007 (+ 17.4%)	0.001
TC	LS T-score	−2.844 ± 0.065	−2.147 ± 0.054	0.697 ± 0.064	0.001
TC	LS BMD	0.679 ± 0.007	0.753 ± 0.006	0.075 ± 0.007 (+ 11.2%)	0.001
TT	LS T-score	−2.921 ± 0.090	− 2.500 ± 0.075	0.421 ± 0.146	0.010
TT	LS BMD	0.670 ± 0.010	0.715 ± 0.008	0.045 ± 0.016 (+ 7.6%)	0.010
CC-TC	LS T-score			0.140 ± 0.083	0.001 for FN T-score and FN BMD	NS
CC-TC	LS BMD			0.015 ± 0.009		NS
CC-TT	LS T-score			0.354 ± 0.094		0.001
CC-TT	LS BMD			0.038 ± 0.010		0.001
TC-TT	LS T-score			0.215 ± 0.080		0.026
TC-TT	LS BMD			0.023 ± 0.009		0.026

BMD of femoral neck (FN) and lumbal spine (LS) is expressed as Estimated Marginal Mean ± SE (SE – standard error of the mean) of T-score (FN and LS T-score) and g/cm² (FN and LS BMD), GLM Sig. – significance of GLM, PC Sig. – significance of pairwise comparisons, NS – non-significant GLM/BMD differences, P values determine significant BMD differences (P < 0.05)

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