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Table 3 Associations of the rs9340799 and rs2234693 genotypes with osteoporosis-related traits

From: The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women

Parameter

rs9340799:A > G genotypes

Sig. (P value)

Sig. Cov.

BMD difference

AA

N = 134

AG + GG

N = 209

BMD-FN (T-score)

−1.716 ± 0.044

−1.837 ± 0.035

0.035

A

0.120 ± 0.570

BMD-FN (g/cm2)

0.587 ± 0.07

0.566 ± 0.06

0.035

A

0.020 ± 0.010

BMD-LS (T-score)

−2.262 ± 0.062

−2.432 ± 0.049

0.033

A, B

0.170 ± 0.079

BMD-LS (g/cm2)

0.741 ± 0.07

0.723 ± 0.05

0.033

A, B

0.018 ± 0.008

ALP

0.493 ± 0.057

0.588 ± 0.046

NS

A, B

 

OC

3.833 ± 0.086

3.853 ± 0.069

NS

A

 

CTx

691.442 ± 21.246

721.324 ± 16.992

NS

A

 

sCa

2.400 ± 0.017

2.399 ± 0.014

NS

A

 

sP

1.191 ± 0.015

1.206 ± 0.012

NS

B

 

Parameter

rs2234693:T > C genotypes

Sig. (P value)

Sig. Cov.

BMD difference

TT

N = 95

TC + CC

N = 248

BMD-FN (T-score)

−1.714 ± 0.053

−1.818 ± 0.032

NS

A

 

BMD-FN (g/cm2)

0.585 ± 0.09

0.570 ± 0.05

NS

A

 

BMD-LS (T-score)

−2.277 ± 0.073

− 2.400 ± 0.045

NS

A, B

 

BMD-LS (g/cm2)

0.739 ± 0.08

0.726 ± 0.05

NS

A, B

 

ALP

0.582 ± 0.068

0.547 ± 0.042

NS

A, B

 

OC

3.926 ± 0.102

3.814 ± 0.063

NS

A

 

CTx

696.002 ± 25.214

714.878 ± 15.592

NS

A

 

sCa

2.394 ± 0.020

2.401 ± 0.013

NS

A

 

sP

1.170 ± 0.018

1.208 ± 0.011

NS

  
  1. Data are presented as Estimated Marginal Mean ± SE (SE – standard error of the mean); values are adjusted for age and BMI BMD-FN – femoral neck BMD (T-score and g/cm2), BMD-LS – lumbal spine BMD (T-score and g/cm2), ALP – bone isoenzyme of alkaline phosphatase (μkat/l), OC - osteocalcin (μg/l), CTx - BetaCrosslaps (ng/l), sCa - serum calcium (mmol/l), sP - serum phosphate (mmol/l), Sig. – significance of GLM/BMD differences, NS – non-significant GLM, P values determine significant GLM/BMD differences (P < 0.05), Sig. Cov. - significance of covariates, A – significant (P < 0.05) covariate Age, B - significant (P < 0.05) covariate BMI