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Table 1 Demographics (Mean ± SD) of Non-Hispanic White Subjects in SPIROMICS

From: Genome-wide association study of lung function and clinical implication in heavy smokers

  Cases Controls P value
  All Current smokers Former smokers All Current smokers Former smokers  
n 1086 325 761 559 210 349 NA
Age at enrollment, years 66.2 ± 7.6 62.9 ± 8.1 67.7 ± 6.9 63.6 ± 9.0 58.0 ± 9.1 66.9 ± 7.0 < 0.0001
Female, n (%) 437 (40) 137 (42) 300 (39) 294 (53) 122 (58) 172 (49) < 0.0001
Body mass index 27.4 ± 5.1 25.7 ± 4.9 28.1 ± 5.0 28.6 ± 5.0 27.5 ± 5.1 29.2 ± 4.8 < 0.0001
Current smokers, n (%) 325 (30) 325 (100) 0 (0) 210 (38) 210 (100) 0 (0) 0.0019
Pack-years of cigarette smoking 55.0 ± 25.7 52.6 ± 24.7 56.0 ± 26.1 46.3 ± 27.3 45.3 ± 31.1 46.9 ± 24.8 < 0.0001
Post-bronchodilator FEV1/FVC 0.52 ± 0.13 0.55 ± 0.11 0.50 ± 0.13 0.77 ± 0.05 0.78 ± 0.05 0.77 ± 0.05 < 0.0001
Post-bronchodilator FEV1, % predicted 60.1 ± 22.5 63.6 ± 19.7 58.6 ± 23.5 94.4 ± 13.9 93.4 ± 13.2 95.0 ± 14.3 < 0.0001
  1. Subjects with available GWAS genotyping information available at current stage were included; Cases: GOLD stage 1–4; Controls: GOLD stage 0