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Table 2 Association of COMT Val158Met with depression and cardiovascular disease; stratified by gender

From: Association of Catechol-O-methyltransferase (COMT Val158Met) with future risk of cardiovascular disease in depressed individuals - a Swedish population-based cohort study

COMT Val158Met Depression Cardiovascular disease (CVD)
All n = 556 Men n = 157 Women n = 399 All n = 236 Men n = 152 Womenn = 84
  n Depressed/n Non-depressed n CVD/n Non-CVD
Met/Met or Met/Val 463/2351 130/1049 333/1302 179/2635 117/1062 62/1573
Val/Val 93/618 27/289 66/329 57/654 35/281 22/373
  Odds ratio (95% confidence interval)a
Met/Met or Met/Val 1 (ref) 1 (ref) 1 (ref) 1 (ref) 1 (ref) 1 (ref)
Val/Val 0.70 (0.60-1.0) 0.74 (0.50-1.1) 0.78 (0.60-1.0) 1.3 (1.0-1.7) 1.1 (0.7-1.7) 1.5 (0.8-2.4)
p value 0.02 0.20 0.11 0.13 0.60 0.13
  1. aOdds ratio (OR) for Val/Val (G/G) was assessed relative to the reference: Met/Met (A/A) plus Met/Val (A/G), adjusted for age and body mass index