Association of Catechol-O-methyltransferase (COMT Val158Met) with future risk of cardiovascular disease in depressed individuals - a Swedish population-based cohort study

Table 2 Association of COMT Val¹⁵⁸Met with depression and cardiovascular disease; stratified by gender

COMT Val¹⁵⁸Met	Depression			Cardiovascular disease (CVD)
COMT Val¹⁵⁸Met	All n = 556	Men n = 157	Women n = 399	All n = 236	Men n = 152	Womenn = 84
	n _Depressed/n _{Non-depressed}			n _CVD/n _Non-CVD
Met/Met or Met/Val	463/2351	130/1049	333/1302	179/2635	117/1062	62/1573
Val/Val	93/618	27/289	66/329	57/654	35/281	22/373
	Odds ratio (95% confidence interval)^a
Met/Met or Met/Val	1 (ref)	1 (ref)	1 (ref)	1 (ref)	1 (ref)	1 (ref)
Val/Val	0.70 (0.60-1.0)	0.74 (0.50-1.1)	0.78 (0.60-1.0)	1.3 (1.0-1.7)	1.1 (0.7-1.7)	1.5 (0.8-2.4)
p value	0.02	0.20	0.11	0.13	0.60	0.13

^aOdds ratio (OR) for Val/Val (G/G) was assessed relative to the reference: Met/Met (A/A) plus Met/Val (A/G), adjusted for age and body mass index

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