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Table 4 Summary of odds ratios (95% CI) in the analysis of the relationship between VEGF gene polymorphisms in rs3025039 and coronary artery disease susceptibility

From: Association of genetic polymorphisms in vascular endothelial growth factor with susceptibility to coronary artery disease: a meta–analysis

Genetic Model Overall and Subgroups N Test of Association Test of Heterogeneity
  OR 95%CI P –value P Heterogeneity I2 (%)
  Overall 8 1.26 0.89,1.79 0.200 0.000 84%
  HWE (yes) 7 1.14 0.86,1.50 0.360 0.020 59%
  PB 2 1.24 0.32,4.77 0.750 0.000 91%
TT + CT vs. CC HB 6 1.17 0.82,1.65 0.390 0.020 63%
  Large sample size 2 1.55 0.67,3.54 0.300 0.000 96%
  Small sample size 6 1.15 0.76,1.75 0.500 0.008 71%
  Asians 4 1.17 0.82,1.65 0.390 0.020 63%
  Caucasians 4 0.91 0.69,1.20 0.40 0.490 0%
  Overall 8 1.38 0.98,1.93 0.060 0.950 0%
  HWE (yes) 7 1.35 0.88,2.05 0.170 0.910 0%
  PB 2 1.34 0.78,2.29 0.290 0.430 0%
TT vs. CC + CT HB 6 1.40 0.91,2.17 0.130 0.910 0%
  Large sample size 2 1.37 0.88,2.14 0.170 0.790 0%
  Small sample size 6 1.40 0.91,2.17 0.130 0.910 0%
  Asians 4 1.45 0.99,2.12 0.060 0.920 0%
  Caucasians 4 1.14 0.55,2.36 0.730 0.710 0%
  Overall 8 1.24 0.86,1.80 0.250 0.000 84%
  HWE (yes) 7 1.11 0.84,1.47 0.440 0.030 58%
  PB 2 1.27 0.33,4.95 0.730 0.001 91%
CT vs. CC HB 6 1.18 0.89,1.56 0.250 0.040 58%
  Large sample size 2 1.55 0.64,3.72 0.330 0.000 96%
  Small sample size 6 1.18 0.89,1.56 0.250 0.040 58%
  Asians 4 1.64 1.01,2.69 0.050 0.000 89%
  Caucasians 4 0.89 0.66,1.19 0.410 0.640 0%
  Overall 8 1.55 1.10,2.17 0.010 0.830 0%
  HWE (yes) 7 1.39 0.91,2.13 0.120 0.820 0%
  PB 2 1.67 0.98,2.85 0.060 0.260 21%
TT vs. CC HB 6 1.47 0.95,2.28 0.080 0.830 0%
  Large sample size 2 1.61 1.03,2.53 0.040 0.410 0%
  Small sample size 6 1.47 0.95,2.28 0.080 0.830 0%
  Asians 4 1.70 1.16,2.50 0.007 0.810 0%
  Caucasians 4 1.10 0.53,2.28 0.810 0.650 0%
  Overall 8 1.23 0.93,1.62 0.140 0.000 80%
  HWE (yes) 7 1.13 0.91,1.42 0.270 0.040 54%
  PB 2 1.17 0.38,3.57 0.780 0.002 90%
T vs. C HB 6 1.19 0.96,1.48 0.110 0.070 51%
  Large sample size 2 1.43 0.76,2.70 0.270 0.000 95%
  Small sample size 6 1.19 0.96,1.48 0.110 0.070 51%
  Asians 4 1.50 1.06,2.13 0.020 0.000 85%
  Caucasians 4 0.94 0.74,1.21 0.640 0.390 0%
  1. Abbreviations: N number of studies; OR odds ratio; CI confidence interval; HB hospital–based; PB population–based; P–Value, P value for association; P Heterogeneity, P value for heterogeneity
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BMC Medical Genetics

ISSN: 1471-2350

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