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Table 4 Summary of odds ratios (95% CI) in the analysis of the relationship between VEGF gene polymorphisms in rs3025039 and coronary artery disease susceptibility

From: Association of genetic polymorphisms in vascular endothelial growth factor with susceptibility to coronary artery disease: a meta–analysis

Genetic Model

Overall and Subgroups

N

Test of Association

Test of Heterogeneity

 

OR

95%CI

P –value

P Heterogeneity

I2 (%)

 

Overall

8

1.26

0.89,1.79

0.200

0.000

84%

 

HWE (yes)

7

1.14

0.86,1.50

0.360

0.020

59%

 

PB

2

1.24

0.32,4.77

0.750

0.000

91%

TT + CT vs. CC

HB

6

1.17

0.82,1.65

0.390

0.020

63%

 

Large sample size

2

1.55

0.67,3.54

0.300

0.000

96%

 

Small sample size

6

1.15

0.76,1.75

0.500

0.008

71%

 

Asians

4

1.17

0.82,1.65

0.390

0.020

63%

 

Caucasians

4

0.91

0.69,1.20

0.40

0.490

0%

 

Overall

8

1.38

0.98,1.93

0.060

0.950

0%

 

HWE (yes)

7

1.35

0.88,2.05

0.170

0.910

0%

 

PB

2

1.34

0.78,2.29

0.290

0.430

0%

TT vs. CC + CT

HB

6

1.40

0.91,2.17

0.130

0.910

0%

 

Large sample size

2

1.37

0.88,2.14

0.170

0.790

0%

 

Small sample size

6

1.40

0.91,2.17

0.130

0.910

0%

 

Asians

4

1.45

0.99,2.12

0.060

0.920

0%

 

Caucasians

4

1.14

0.55,2.36

0.730

0.710

0%

 

Overall

8

1.24

0.86,1.80

0.250

0.000

84%

 

HWE (yes)

7

1.11

0.84,1.47

0.440

0.030

58%

 

PB

2

1.27

0.33,4.95

0.730

0.001

91%

CT vs. CC

HB

6

1.18

0.89,1.56

0.250

0.040

58%

 

Large sample size

2

1.55

0.64,3.72

0.330

0.000

96%

 

Small sample size

6

1.18

0.89,1.56

0.250

0.040

58%

 

Asians

4

1.64

1.01,2.69

0.050

0.000

89%

 

Caucasians

4

0.89

0.66,1.19

0.410

0.640

0%

 

Overall

8

1.55

1.10,2.17

0.010

0.830

0%

 

HWE (yes)

7

1.39

0.91,2.13

0.120

0.820

0%

 

PB

2

1.67

0.98,2.85

0.060

0.260

21%

TT vs. CC

HB

6

1.47

0.95,2.28

0.080

0.830

0%

 

Large sample size

2

1.61

1.03,2.53

0.040

0.410

0%

 

Small sample size

6

1.47

0.95,2.28

0.080

0.830

0%

 

Asians

4

1.70

1.16,2.50

0.007

0.810

0%

 

Caucasians

4

1.10

0.53,2.28

0.810

0.650

0%

 

Overall

8

1.23

0.93,1.62

0.140

0.000

80%

 

HWE (yes)

7

1.13

0.91,1.42

0.270

0.040

54%

 

PB

2

1.17

0.38,3.57

0.780

0.002

90%

T vs. C

HB

6

1.19

0.96,1.48

0.110

0.070

51%

 

Large sample size

2

1.43

0.76,2.70

0.270

0.000

95%

 

Small sample size

6

1.19

0.96,1.48

0.110

0.070

51%

 

Asians

4

1.50

1.06,2.13

0.020

0.000

85%

 

Caucasians

4

0.94

0.74,1.21

0.640

0.390

0%

  1. Abbreviations: N number of studies; OR odds ratio; CI confidence interval; HB hospital–based; PB population–based; P–Value, P value for association; P Heterogeneity, P value for heterogeneity
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BMC Medical Genetics

ISSN: 1471-2350

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