|
Genetic Model
|
Overall and Subgroups
|
N
|
Test of Association
|
Test of Heterogeneity
|
|---|
| |
OR
|
95%CI
|
P
–value
|
P
Heterogeneity
|
I2 (%)
|
|---|
| |
Overall
|
10
|
1.18
|
0.94,1.48
|
0.140
|
0.002
|
65%
|
| |
PB
|
3
|
1.31
|
0.77,2.25
|
0.320
|
0.020
|
74%
|
|
CC + GC vs. GG
|
HB
|
7
|
1.13
|
0.88,1.44
|
0.340
|
0.010
|
62%
|
| |
Large sample size
|
4
|
1.11
|
0.77,1.58
|
0.580
|
0.009
|
74%
|
| |
Small sample size
|
6
|
1.25
|
0.92,1.68
|
0.150
|
0.030
|
60%
|
| |
Asians
|
6
|
1.22
|
0.93,1.59
|
0.140
|
0.010
|
67%
|
| |
Caucasians
|
4
|
1.09
|
0.68,1.76
|
0.720
|
0.010
|
72%
|
| |
Overall
|
10
|
1.45
|
1.03,2.05
|
0.030
|
0.000
|
74%
|
| |
PB
|
3
|
1.26
|
0.64,2.48
|
0.500
|
0.050
|
67%
|
|
CC vs. GG + GC
|
HB
|
7
|
1.56
|
0.97,2.53
|
0.070
|
0.000
|
79%
|
| |
Large sample size
|
4
|
1.43
|
0.74,2.74
|
0.290
|
0.000
|
72%
|
| |
Small sample size
|
6
|
1.52
|
1.01,2.33
|
0.040
|
0.050
|
55%
|
| |
Asians
|
6
|
1.50
|
0.98,2.31
|
0.060
|
0.000
|
82%
|
| |
Caucasians
|
4
|
1.35
|
0.70,2.60
|
0.370
|
0.110
|
51%
|
| |
Overall
|
10
|
1.18
|
0.90,1.57
|
0.240
|
0.000
|
76%
|
| |
PB
|
3
|
1.32
|
0.88,1.98
|
0.180
|
0.130
|
51%
|
|
GC vs. GG
|
HB
|
7
|
1.14
|
0.79,1.64
|
0.490
|
0.000
|
81%
|
| |
Large sample size
|
4
|
1.28
|
0.72,2.28
|
0.400
|
0.060
|
65%
|
| |
Small sample size
|
6
|
1.14
|
0.89,1.46
|
0.290
|
0.190
|
32%
|
| |
Asians
|
6
|
1.25
|
0.85,1.84
|
0.260
|
0.000
|
83%
|
| |
Caucasians
|
4
|
1.08
|
0.72,1.63
|
0.710
|
0.060
|
59%
|
| |
Overall
|
10
|
1.57
|
1.02,2.42
|
0.040
|
0.000
|
77%
|
| |
PB
|
3
|
1.47
|
0.60,3.63
|
0.400
|
0.020
|
74%
|
|
CC vs. GG
|
HB
|
7
|
1.60
|
0.93,2.77
|
0.090
|
0.000
|
81%
|
| |
Large sample size
|
4
|
1.24
|
0.68,2.28
|
0.480
|
0.000
|
71%
|
| |
Small sample size
|
6
|
2.03
|
1.26,3.28
|
0.007
|
0.070
|
50%
|
| |
Asians
|
6
|
1.62
|
0.94,2.79
|
0.080
|
0.000
|
84%
|
| |
Caucasians
|
4
|
1.40
|
0.42,4.61
|
0.580
|
0.002
|
73%
|
| |
Overall
|
10
|
1.19
|
0.98,1.44
|
0.080
|
0.000
|
78%
|
| |
PB
|
3
|
1.15
|
0.77,1.73
|
0.500
|
0.006
|
81%
|
|
C vs. G
|
HB
|
7
|
1.20
|
0.94,1.53
|
0.140
|
0.000
|
80%
|
| |
Large sample size
|
4
|
1.10
|
0.84,1.43
|
0.490
|
0.001
|
814%
|
| |
Small sample size
|
6
|
1.27
|
1.03,1.78
|
0.030
|
0.010
|
72%
|
| |
Asians
|
6
|
1.24
|
0.98,1.58
|
0.070
|
0.000
|
83%
|
| |
Caucasians
|
4
|
1.08
|
0.73,1.60
|
0.690
|
0.006
|
76%
|
- Abbreviations: N number of studies; OR odds ratio; CI confidence interval; HB hospital–based; PB population–based; P–Value, P value for association; P Heterogeneity, P value for heterogeneity
