Skip to main content

Table 3 Summary of odds ratios (95% CI) in the analysis of the relationship between VEGF gene polymorphisms in rs2010963 and coronary artery disease susceptibility

From: Association of genetic polymorphisms in vascular endothelial growth factor with susceptibility to coronary artery disease: a meta–analysis

Genetic Model

Overall and Subgroups

N

Test of Association

Test of Heterogeneity

 

OR

95%CI

P –value

P Heterogeneity

I2 (%)

 

Overall

10

1.18

0.94,1.48

0.140

0.002

65%

 

PB

3

1.31

0.77,2.25

0.320

0.020

74%

CC + GC vs. GG

HB

7

1.13

0.88,1.44

0.340

0.010

62%

 

Large sample size

4

1.11

0.77,1.58

0.580

0.009

74%

 

Small sample size

6

1.25

0.92,1.68

0.150

0.030

60%

 

Asians

6

1.22

0.93,1.59

0.140

0.010

67%

 

Caucasians

4

1.09

0.68,1.76

0.720

0.010

72%

 

Overall

10

1.45

1.03,2.05

0.030

0.000

74%

 

PB

3

1.26

0.64,2.48

0.500

0.050

67%

CC vs. GG + GC

HB

7

1.56

0.97,2.53

0.070

0.000

79%

 

Large sample size

4

1.43

0.74,2.74

0.290

0.000

72%

 

Small sample size

6

1.52

1.01,2.33

0.040

0.050

55%

 

Asians

6

1.50

0.98,2.31

0.060

0.000

82%

 

Caucasians

4

1.35

0.70,2.60

0.370

0.110

51%

 

Overall

10

1.18

0.90,1.57

0.240

0.000

76%

 

PB

3

1.32

0.88,1.98

0.180

0.130

51%

GC vs. GG

HB

7

1.14

0.79,1.64

0.490

0.000

81%

 

Large sample size

4

1.28

0.72,2.28

0.400

0.060

65%

 

Small sample size

6

1.14

0.89,1.46

0.290

0.190

32%

 

Asians

6

1.25

0.85,1.84

0.260

0.000

83%

 

Caucasians

4

1.08

0.72,1.63

0.710

0.060

59%

 

Overall

10

1.57

1.02,2.42

0.040

0.000

77%

 

PB

3

1.47

0.60,3.63

0.400

0.020

74%

CC vs. GG

HB

7

1.60

0.93,2.77

0.090

0.000

81%

 

Large sample size

4

1.24

0.68,2.28

0.480

0.000

71%

 

Small sample size

6

2.03

1.26,3.28

0.007

0.070

50%

 

Asians

6

1.62

0.94,2.79

0.080

0.000

84%

 

Caucasians

4

1.40

0.42,4.61

0.580

0.002

73%

 

Overall

10

1.19

0.98,1.44

0.080

0.000

78%

 

PB

3

1.15

0.77,1.73

0.500

0.006

81%

C vs. G

HB

7

1.20

0.94,1.53

0.140

0.000

80%

 

Large sample size

4

1.10

0.84,1.43

0.490

0.001

814%

 

Small sample size

6

1.27

1.03,1.78

0.030

0.010

72%

 

Asians

6

1.24

0.98,1.58

0.070

0.000

83%

 

Caucasians

4

1.08

0.73,1.60

0.690

0.006

76%

  1. Abbreviations: N number of studies; OR odds ratio; CI confidence interval; HB hospital–based; PB population–based; P–Value, P value for association; P Heterogeneity, P value for heterogeneity