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Table 1 Characteristics of the individual studies included in the meta–analysis

From: Association of genetic polymorphisms in vascular endothelial growth factor with susceptibility to coronary artery disease: a meta–analysis

Study Country Ethnicity Disease Control Source Genotyping Methods Sample Size Cases/Controls Genotype Distribution PHWE NOS
Cases Controls
rs699947        AA/AC/CC AA/AC/CC   
Biselli 200823 Brazil Caucasian CAD HB PCR 175/108 32/96/47 27/51/30 0.569 6
Kangas–Kontio 200925 Finland Caucasian MI HB TaqMan 188/218 64/87/37 77/101/40 0.498 7
Chen 201126 UK Caucasian MI PB PCR–RFLP 46/372 10/34/2 100/167/105 0.050 8
Amoli 201227 Iran Asian CAD HB PCR 50/50 9/26/15 14/27/9 0.520 6
Cui 201328 China Asian CAD HB PCR 242/253 27/78/137 12/69/172 0.148 6
Gu 201329 China Asian CAD HB MassARRAY 427/472 30/178/219 31/174/267 0.713 6
Li 201622 China Asian CAD PB PCR 533/533 180/250/103 217/237/79 0.280 8
Liu 201631 China Asian CAD PB PCR 810/805 275/381/154 339/345/121 0.03 8
rs2010963        GG/GC/CC GG/GC/CC   
Petrovic 200724 Slovenia Caucasian MI PB PCR 143/228 42/76/25 103/104/21 0.470 7
Kangas–Kontio 200925 Finland Caucasian MI HB TaqMan 186/218 113/61/12 143/67/8 0.966 7
Chen 201126 UK Caucasian MI PB PCR–RFLP 46/372 26/19/1 174/159/39 0.765 8
Cui 201328 China Asian CAD HB PCR 242/253 75/102/65 104/114/35 0.675 6
Gu 201329 China Asian CAD HB MassARRAY 419/468 144/215/60 154/225/89 0.672 6
Douvaras 201332 Greece Caucasian MI HB PCR–RFLP 102/98 37/49/16 29/55/14 > 0.050 7
Moradzadegan 201530 Iran Asian CAD HB PCR–RFLP 141/369 43/65/33 85/197/87 0.193 7
Han 201521 China Asian CAD HB MassARRAY 144/150 69/49/26 86/54/10 0.701 6
Li 201622 China Asian CAD PB PCR 533/533 50/233/250 71/239/223 0.583 8
Nia 201733 Iran Asian CAD HB TaqMan 347/173 167/135/45 102/63/8 > 0.050 7
rs3025039        CC/CT/TT CC/CT/TT   
Biselli 200823 Brazil Caucasian CAD HB PCR 175/108 133/36/6 83/23/2 0.783 6
Kangas–Kontio 200925 Finland Caucasian MI HB TaqMan 187/218 140/42/5 155/56/7 0.488 7
Chen 201126 UK Caucasian MI PB PCR–RFLP 46/372 37/8/1 264/95/13 0.229 8
Cui 201328 China Asian CAD HB PCR 242/253 133/95/14 159/86/8 0.373 6
Gu 201329 China Asian CAD HB MassARRAY 430/473 272/142/16 300/159/14 0.194 6
Douvaras 201332 Greece Caucasian MI HB PCR–RFLP 102/98 68/30/4 69/27/2 > 0.050 7
Han 201521 China Asian CAD HB MassARRAY 144/150 84/55/5 115/31/4 0.290 6
Liu 201631 China Asian CAD PB PCR 810/805 472/308/30 617/167/21 0.020 8
rs1570360        GG/GA/AA GG/GA/AA   
Biselli 200823 Brazil Caucasian CAD HB PCR 175/108 96/61/18 57/38/13 0.104 6
Cui 201328 China Asian CAD HB PCR 242/253 151/79/12 172/69/12 0.148 6
Liu 201631 China Asian CAD PB PCR 810/805 54/370/386 137/456/212 > 0.050 8
  1. Abbreviations: CAD coronary artery disease; MI myocardial infarction; PCR polymerase chain reaction; PCR–RFLP polymerase chain reaction-restriction fragment length polymorphism; HWE Hardy–Weinberg equilibrium; PB population–based; HB hospital–based; NOS Newcastle–Ottawa quality scale; UK the United Kingdom
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BMC Medical Genetics

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