Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 3 Association between CDKN2A/2B (rs10811661), SLC30A8 (rs13266634), and TCF7L2 (rs7903146) genotypes and quantitative traits among Thai patients with T2D

From: Impact of KCNQ1, CDKN2A/2B, CDKAL1, HHEX, MTNR1B, SLC30A8, TCF7L2, and UBE2E2 on risk of developing type 2 diabetes in Thai population

Clinical characteristics CDKN2A/2B (rs10811661) genotypes SLC30A8 (rs13266634) genotypes TCF7L2 (rs7903146) genotypes
T/T T/C C/C P C/C C/T T/T P C/C C/T + TT P
Number of patients 228 220 52 172 242 86 429 71
Weight (kg) 68.99 ± 13.96 67.42 ± 13.73 65.01 ± 14.28 0.250 66.38 ± 14.78 66.38 ± 14.78 66.38 ± 14.78 0.867 67.58 ± 13.60 68.83 ± 15.45 0.172
Waist circumference (cm) 89.34 ± 11.32 89.39 ± 11.69 92.59 ± 11.04 0.007 89.55 ± 11.58 89.79 ± 10.82 89.87 ± 12.75 0.506 89.66 ± 11.30 89.84 ± 12.27 0.861
Waist-to-hip ratio 0.89 ± 0.07 0.91 ± 0.08 0.92 ± 0.11 0.023 0.91 ± 0.07 0.90 ± 0.08 0.90 ± 0.08 0.263 0.90 ± 0.08 0.90 ± 0.080 0.334
BMI (kg/m2) 27.60 ± 5.06 27.07 ± 4.99 26.82 ± 5.075 0.442 26.65 ± 5.15 27.62 ± 4.72 27.59 ± 5.38 0.273 27.27 ± 5.067 27.14 ± 4.71 0.736
SBP (mmHg) 133.60 ± 19.99 134.21 ± 17.58 143.52 ± 23.29 0.746 134.94 ± 18.56 134.44 ± 19.30 136.47 ± 21.82 0.740 135.25 ± 19.64 132.98 ± 18.15 0.800
DBP (mmHg) 78.84 ± 10.72 79.42 ± 9.87 80.75 ± 11.65 0.228 79.95 ± 10.16 78.56 ± 10.85 80.18 ± 9.89 0.348 79.43 ± 10.62 78.87 ± 9.21 0.469
FPG (mmol/l) 9.27 (7.05, 12.49) 8.16 (6.38, 11.88) 7.79 (6.33, 10.68) 0.244 8.33 (6.64, 11.62) 8.49 (6.38, 12.93) 8.77 (6.84, 11.94) 0.164 8.49 (6.50, 12.25) 8.55 (6.94, 8.55) 0.721
HbA1c (mmol/mol) 59.05 (49.70, 78.92) 56.30 (48.6, 71.6) 53.00 (44.82, 77.3) 0.683 56.30 (48.6, 71.6) 57.40 (49.7, 76.5) 59.05 (48.32, 78.10) 0.018 57.40 (48.60, 74.9) 56.30 (47.50, 56.30) 0.535
TC (mmol/l) 202.96 ± 53.19 197.52 ± 51.12 195.80 ± 60.28 0.748 197.40 ± 55.56 199.65 ± 51.20 208.33 ± 55.57 0.853 200.65 ± 54.08 198.00 ± 49.65 0.592
TG (mmol/l) 1.46 (1.03, 2.06) 1.50 (1.18, 2.11) 1.64 (1.17, 2.06) 0.197 1.43 (1.02, 2.05) 1.51 (1.14, 2.08) 1.51 (1.18, 2.26) 0.664 1.52 (1.15, 2.10) 1.32 (1.06, 1.32) 0.600
LDL-C (mmol/l) 2.22 (1.39, 3.85) 2.15 (1.30, 3.50) 1.47 (1.10, 2.87) 0.943 1.89 (1.34, 3.64) 2.38 (1.22, 3.78) 2.22 (1.37, 3.71) 0.854 2.17 (1.33, 3.68) 1.71 (1.16, 1.71) 0.741
HDL-C (mmol/l) 1.58 (1.14, 2.21) 1.63 (1.19, 2.265) 1.78 (1.44, 2.32) 0.965 1.64 (1.17, 2.24) 1.61 (1.19, 2.17) 1.55 (1.14, 2.50) 0.464 1.60 (1.16, 2.18) 1.81 (1.34, 1.81) 0.023
  1. Data presented as mean ± standard deviation or median and interquartile range
  2. P-values were calculated using linear regression after adjusting for age, gender, BMI, and medication, as appropriate. FPG, HbA1c, TG, LDL-C, and HDL-C values were log-transformed to improve normality before regression analysis
  3. Abbreviations: T2D type 2 diabetes, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA 1c glycated hemoglobin, TC, total cholesterol, TG, triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol