Clinical characteristics | CDKN2A/2B (rs10811661) genotypes | SLC30A8 (rs13266634) genotypes | TCF7L2 (rs7903146) genotypes | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
T/T | T/C | C/C | P | C/C | C/T | T/T | P | C/C | C/T + TT | P | |
Number of patients | 228 | 220 | 52 | – | 172 | 242 | 86 | – | 429 | 71 | – |
Weight (kg) | 68.99 ± 13.96 | 67.42 ± 13.73 | 65.01 ± 14.28 | 0.250 | 66.38 ± 14.78 | 66.38 ± 14.78 | 66.38 ± 14.78 | 0.867 | 67.58 ± 13.60 | 68.83 ± 15.45 | 0.172 |
Waist circumference (cm) | 89.34 ± 11.32 | 89.39 ± 11.69 | 92.59 ± 11.04 | 0.007 | 89.55 ± 11.58 | 89.79 ± 10.82 | 89.87 ± 12.75 | 0.506 | 89.66 ± 11.30 | 89.84 ± 12.27 | 0.861 |
Waist-to-hip ratio | 0.89 ± 0.07 | 0.91 ± 0.08 | 0.92 ± 0.11 | 0.023 | 0.91 ± 0.07 | 0.90 ± 0.08 | 0.90 ± 0.08 | 0.263 | 0.90 ± 0.08 | 0.90 ± 0.080 | 0.334 |
BMI (kg/m2) | 27.60 ± 5.06 | 27.07 ± 4.99 | 26.82 ± 5.075 | 0.442 | 26.65 ± 5.15 | 27.62 ± 4.72 | 27.59 ± 5.38 | 0.273 | 27.27 ± 5.067 | 27.14 ± 4.71 | 0.736 |
SBP (mmHg) | 133.60 ± 19.99 | 134.21 ± 17.58 | 143.52 ± 23.29 | 0.746 | 134.94 ± 18.56 | 134.44 ± 19.30 | 136.47 ± 21.82 | 0.740 | 135.25 ± 19.64 | 132.98 ± 18.15 | 0.800 |
DBP (mmHg) | 78.84 ± 10.72 | 79.42 ± 9.87 | 80.75 ± 11.65 | 0.228 | 79.95 ± 10.16 | 78.56 ± 10.85 | 80.18 ± 9.89 | 0.348 | 79.43 ± 10.62 | 78.87 ± 9.21 | 0.469 |
FPG (mmol/l) | 9.27 (7.05, 12.49) | 8.16 (6.38, 11.88) | 7.79 (6.33, 10.68) | 0.244 | 8.33 (6.64, 11.62) | 8.49 (6.38, 12.93) | 8.77 (6.84, 11.94) | 0.164 | 8.49 (6.50, 12.25) | 8.55 (6.94, 8.55) | 0.721 |
HbA1c (mmol/mol) | 59.05 (49.70, 78.92) | 56.30 (48.6, 71.6) | 53.00 (44.82, 77.3) | 0.683 | 56.30 (48.6, 71.6) | 57.40 (49.7, 76.5) | 59.05 (48.32, 78.10) | 0.018 | 57.40 (48.60, 74.9) | 56.30 (47.50, 56.30) | 0.535 |
TC (mmol/l) | 202.96 ± 53.19 | 197.52 ± 51.12 | 195.80 ± 60.28 | 0.748 | 197.40 ± 55.56 | 199.65 ± 51.20 | 208.33 ± 55.57 | 0.853 | 200.65 ± 54.08 | 198.00 ± 49.65 | 0.592 |
TG (mmol/l) | 1.46 (1.03, 2.06) | 1.50 (1.18, 2.11) | 1.64 (1.17, 2.06) | 0.197 | 1.43 (1.02, 2.05) | 1.51 (1.14, 2.08) | 1.51 (1.18, 2.26) | 0.664 | 1.52 (1.15, 2.10) | 1.32 (1.06, 1.32) | 0.600 |
LDL-C (mmol/l) | 2.22 (1.39, 3.85) | 2.15 (1.30, 3.50) | 1.47 (1.10, 2.87) | 0.943 | 1.89 (1.34, 3.64) | 2.38 (1.22, 3.78) | 2.22 (1.37, 3.71) | 0.854 | 2.17 (1.33, 3.68) | 1.71 (1.16, 1.71) | 0.741 |
HDL-C (mmol/l) | 1.58 (1.14, 2.21) | 1.63 (1.19, 2.265) | 1.78 (1.44, 2.32) | 0.965 | 1.64 (1.17, 2.24) | 1.61 (1.19, 2.17) | 1.55 (1.14, 2.50) | 0.464 | 1.60 (1.16, 2.18) | 1.81 (1.34, 1.81) | 0.023 |