Fig. 2
From: An inherited FGFR2 mutation increased osteogenesis gene expression and result in Crouzon syndrome
A heterozygous missense mutation was identified in FGFR2. a A heterozygous missense mutationin exon 10 of the FGFR2 was identified in Crouzon syndromepatients which was absent in normal population. b Mapping of pathogenic FGFR2 mutations. c Amino acid sequence of FGFR2 around G338R in species of the vertebrates and FGFR family, a highly conserved segment of the FGFR2 protein. d Molecular modelling of the immunoglobulin (Ig)-like domain 3 of the wild-type and mutant-typep.G338RFGFR2