Fig. 3

3D homology model of WT S1PR2 protein structure. a Description of the single helices. Helix I includes the N-terminal end and is colored in green. Helix II (turquoise) and helix III (blue) form ECL1, helix IV (purple) and helix V (red) form ECL2, and helix VI (pink) and helix VII (yellow) form ECL3. L represents the ligand ML056, which mirrors the S1P ligand. b View of S1PR2 from the extracellular side. The ECLs and N-terminal end are marked. L describes the ligand ML056. c Partial human protein sequence alignments of S1PR2 and S1PR1 including p.108 and p.120, respectively