Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China

Table 3 Clinicopathological features and APEX1 and OGG1 gene polymorphisms

Clinical features	SNPs	Genotype	N (%)		OR (95% CI)^a	P value
Clinical features	SNPs	Genotype	Positive	Negative	OR (95% CI)^a	P value
APEX1
ER	rs1130409	GG	48(14.55)	38(22.35)	Reference
		GT	158(47.88)	74(43.53)	1.709(1.028-2.842)	0.039
		TT	124(37.58)	58(34.12)	1.725(1.016-2.930)	0.043
		Dominant^b			1.716(1.068-2.759)	0.026
		Recessive^c			1.174(0.796-1.732)	0.417
	rs3136817	TT	267(80.91)	130(76.47)	Reference
		TC	59(17.88)	37(21.76)	0.779(0.491-1.236)	0.288
		CC	4(1.21)	3(1.76)	0.673(0.148-3.063)	0.608
		Dominant			0.771(0.492-1.207)	0.255
		Recessive			0.708(0.156-3.213)	0.655
Her-2	rs1130409	GG	27(23.08)	59(15.57)	Reference
		GT	56(47.86)	176(46.44)	0.689(0.399-1.190)	0.182
		TT	34(29.06)	144(37.99)	0.508(0.281-0.917)	0.025
		Dominant			0.608(0.364-1.015)	0.057
		Recessive			0.663(0.423-1.040)	0.074
	rs3136817	TT	95(81.20)	298(78.63)	Reference
		TC	21(17.95)	75(19.79)	0.875(0.512-1.497)	0.627
		CC	1(0.85)	6(1.58)	0.505(0.060-4.265)	0.531
		Dominant			0.848(0.501-1.433)	0.537
		Recessive			0.519(0.062-4.365)	0.546
Ki-67	rs3136817	TT	239(80.20)	134(77.91)	Reference
		TC	54(18.12)	36(20.93)	0.842(0.525-1.350)	0.475
		CC	5(1.68)	2(1.16)	1.451(0.277-7.610)	0.660
		Dominant			0.873(0.552-1.383)	0.564
		Recessive			1.502(0.287-7.854)	0.630
OGG1
Ki-67	rs2072668	CC	55(18.46)	21(12.21)	Reference
		CG	146(48.99)	82(47.67)	0.675(0.381-1.195)	0.178
		GG	97(32.55)	69(40.12)	0.536(0.297-0.968)	0.039
		Dominant			0.612(0.355-1.052)	0.076
		Recessive			0.913(0.620-1.344)	0.644

ER estrogen receptor, Her-2 human epidermal growth factor receptor 2, Ki-67 monoclonal antibody Ki-67, OR odds ratio, CI confidence interval;
^aORs were adjusted for age;
^bThe dominant model: comparing the combination of heterozygotes and minor allele homozygotes with the major allele homozygotes;
^cThe recessive model: comparing minor allele homozygotes with the combination of heterozygotes and major allele homozygotes

ISSN: 1471-2350