Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China

Table 2 Genotype frequencies of APEX1 and OGG1 gene polymorphisms in controls and cases and their associations with breast cancer

SNPs	Genotype	Case N (%)	Control N (%)	OR (95% CI)^a	P value
APEX1
rs1130409	GG	91(17.57)	150(16.29)	Reference
	GT	242(46.72)	417(45.28)	0.955(0.703-1.298)	0.770
	TT	185(35.71)	354(38.44)	0.864(0.629-1.187)	0.368
	G	424(40.93)	717(38.93)	Reference
	T	612(59.07)	1125(61.07)	0.922(0.789-1.078)	0.309
	Dominant^b			0.914(0.685-1.218)	0.538
	Recessive^c			0.894(0.714-1.119)	0.328
rs3136817	TT	412(79.54)	668(72.53)	Reference
	TC	99(19.11)	240(26.06)	0.670(0.513-0.873)	0.003
	CC	7(1.35)	13(1.41)	0.915(0.359-2.329)	0.851
	T	923(89.09)	1576(85.56)	Reference
	C	113(10.91)	266(14.44)	0.729(0.576-0.923)	0.009
	Dominant			0.682(0.526-0.883)	0.004
	Recessive			1.002(0.394-2.547)	0.996
OGG1
rs2072668	CC	83(16.02)	156(16.94)	Reference
	CG	253(48.84)	440(47.77)	1.072(0.786-1.461)	0.661
	GG	182(35.14)	325(35.29)	1.056(0.763-1.459)	0.744
	C	419(40.44)	752(40.83)	Reference
	G	617(59.56)	1090(59.17)	1.019(0.872-1.191)	0.811
	Dominant			1.065(0.795-1.427)	0.673
	Recessive			1.002(0.799-1.258)	0.984
rs1052133	CC	87(16.80)	154(16.72)	Reference
	CG	243(46.91)	431(46.80)	0.986(0.725-1.342))	0.928
	GG	188(36.29)	336(36.48)	0.985(0.715-1.356)	0.925
	C	417(40.25)	739(40.12)	Reference
	G	619(59.75)	1103(59.88)	0.993(0.850-1.161)	0.934
	Dominant			0.985(0.738-1.317)	0.921
	Recessive			0.995(0.795-1.246)	0.966

OR odds ratio, CI confidence interval;
^aORs were adjusted for age;
^bThe dominant model: comparing the combination of heterozygotes and minor allele homozygotes with the major allele homozygotes;
^cThe recessive model: comparing minor allele homozygotes with the combination of heterozygotes and major allele homozygotes

ISSN: 1471-2350