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Table 4 Genotype, allele and haplotype frequencies of STAT3 rs1053004 and rs1053005 polymorphisms in patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma

From: Association of polymorphism rs1053005 in STAT3 with chronic hepatitis B virus infection in Han Chinese population

STAT3 polymorphism CH (n = 239) LC (n = 141) HCC (n = 187) CH vs. LC CH vs. HCC LC vs. HCC
P OR (95%CI) P OR (95%CI) P OR (95%CI)
rs1053004
 Genotype
  TT 108 (45.2) 76 (53.9) 82 (43.9) Ref.   Ref.   Ref.  
  TC 103 (43.1) 50 (35.4) 82 (43.9) 0.103 0.690 (0.441–1.079) 0.820 1.049 (0.697–1.577) 0.103 1.520 (0.950–2.432)
  CC 28 (11.7) 15 (10.6) 23 (12.2) 0.439 1.314 (0.657–2.625) 0.804 0.924 (0.496–1.721) 0.338 0.704 (0.342–1.448)
 Allele
  T 319 (66.7) 202 (71.6) 246 (65.8) Ref.   Ref.   Ref.  
  C 159 (33.3) 80 (28.4) 128 (34.2) 0.160 1.259 (0.913–1.735) 0.768 1.044 (0.784–1.390) 0.111 0.761 (0.544–1.065)
rs1053005
 Genotype
  AA 110 (46.0) 78 (55.3) 83 (44.4) Ref.   Ref.   Ref.  
  AG 104 (43.5) 51 (36.2) 84 (44.9) 0.102 1.446 (0.928–2.252) 0.742 0.934 (0.623–1.400) 0.065 0.646 (0.406–1.029)
  GG 25 (10.5) 12 (8.5) 20 (10.7) 0.304 1.477 (0.700–3.118) 0.861 0.943 (0.491–1.813) 0.257 0.638 (0.293–1.392)
 Allele
  A 324 (67.8) 207 (73.4) 250 (66.8) Ref.   Ref.   Ref.  
  G 154 (32.2) 75 (26.6) 124 (33.2) 0.103 1.312 (0.946–1.818) 0.772 0.958 (0.718–1.279) 0.070 1.369 (0.974–1.925)
Haplotype (rs1053004-rs1053005)
 T-A 319 (66.7) 202 (71.6) 246 (65.8) Ref.   Ref.   Ref.  
 C-G 154 (32.2) 75 (26.6) 124 (33.2) 0.116 1.300 (0.937–1.804) 0.770 1.044 (0.782–1.394) 0.079 1.358 (0.965–1.911)
 T-G 0 (0) 0 (0) 4 (1.8) 1.000 1.000 (1.000–1.000) 0.023a 0.435 (0.396–0.478) 0.025b 0.549 (0.505–0.597)
 C-A 5 (1.2) 5 (1.0) 0 (0) 0.471 1.579 (0.452–5.523) 0.050c 1.771 (1.647–1.904) 0.014d 2.218 (2.002–2.456)
  1. Data are presented as n (%). CH chronic hepatitis, LC liver cirrhosis, HCC hepatocellular carcinoma, OR odds ratio, 95%CI 95% confidence interval, Ref. reference. a P value by Bonferroni correction = 0.069; bP value by Bonferroni correction = 0.075; cP value by Bonferroni correction = 0.150; dP value by Bonferroni correction = 0.042