Table 4 Genotype, allele and haplotype frequencies of STAT3 rs1053004 and rs1053005 polymorphisms in patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma
STAT3 polymorphism | CH (n = 239) | LC (n = 141) | HCC (n = 187) | CH vs. LC | CH vs. HCC | LC vs. HCC | |||
|---|---|---|---|---|---|---|---|---|---|
P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | ||||
rs1053004 | |||||||||
Genotype | |||||||||
TT | 108 (45.2) | 76 (53.9) | 82 (43.9) | Ref. | Ref. | Ref. | |||
TC | 103 (43.1) | 50 (35.4) | 82 (43.9) | 0.103 | 0.690 (0.441–1.079) | 0.820 | 1.049 (0.697–1.577) | 0.103 | 1.520 (0.950–2.432) |
CC | 28 (11.7) | 15 (10.6) | 23 (12.2) | 0.439 | 1.314 (0.657–2.625) | 0.804 | 0.924 (0.496–1.721) | 0.338 | 0.704 (0.342–1.448) |
Allele | |||||||||
T | 319 (66.7) | 202 (71.6) | 246 (65.8) | Ref. | Ref. | Ref. | |||
C | 159 (33.3) | 80 (28.4) | 128 (34.2) | 0.160 | 1.259 (0.913–1.735) | 0.768 | 1.044 (0.784–1.390) | 0.111 | 0.761 (0.544–1.065) |
rs1053005 | |||||||||
Genotype | |||||||||
AA | 110 (46.0) | 78 (55.3) | 83 (44.4) | Ref. | Ref. | Ref. | |||
AG | 104 (43.5) | 51 (36.2) | 84 (44.9) | 0.102 | 1.446 (0.928–2.252) | 0.742 | 0.934 (0.623–1.400) | 0.065 | 0.646 (0.406–1.029) |
GG | 25 (10.5) | 12 (8.5) | 20 (10.7) | 0.304 | 1.477 (0.700–3.118) | 0.861 | 0.943 (0.491–1.813) | 0.257 | 0.638 (0.293–1.392) |
Allele | |||||||||
A | 324 (67.8) | 207 (73.4) | 250 (66.8) | Ref. | Ref. | Ref. | |||
G | 154 (32.2) | 75 (26.6) | 124 (33.2) | 0.103 | 1.312 (0.946–1.818) | 0.772 | 0.958 (0.718–1.279) | 0.070 | 1.369 (0.974–1.925) |
Haplotype (rs1053004-rs1053005) | |||||||||
T-A | 319 (66.7) | 202 (71.6) | 246 (65.8) | Ref. | Ref. | Ref. | |||
C-G | 154 (32.2) | 75 (26.6) | 124 (33.2) | 0.116 | 1.300 (0.937–1.804) | 0.770 | 1.044 (0.782–1.394) | 0.079 | 1.358 (0.965–1.911) |
T-G | 0 (0) | 0 (0) | 4 (1.8) | 1.000 | 1.000 (1.000–1.000) | 0.023a | 0.435 (0.396–0.478) | 0.025b | 0.549 (0.505–0.597) |
C-A | 5 (1.2) | 5 (1.0) | 0 (0) | 0.471 | 1.579 (0.452–5.523) | 0.050c | 1.771 (1.647–1.904) | 0.014d | 2.218 (2.002–2.456) |