|
STAT3 polymorphism
|
CH (n = 239)
|
LC (n = 141)
|
HCC (n = 187)
|
CH vs. LC
|
CH vs. HCC
|
LC vs. HCC
|
|---|
|
P
|
OR (95%CI)
|
P
|
OR (95%CI)
|
P
|
OR (95%CI)
|
|---|
|
rs1053004
|
|
Genotype
|
|
TT
|
108 (45.2)
|
76 (53.9)
|
82 (43.9)
|
Ref.
| |
Ref.
| |
Ref.
| |
|
TC
|
103 (43.1)
|
50 (35.4)
|
82 (43.9)
|
0.103
|
0.690 (0.441–1.079)
|
0.820
|
1.049 (0.697–1.577)
|
0.103
|
1.520 (0.950–2.432)
|
|
CC
|
28 (11.7)
|
15 (10.6)
|
23 (12.2)
|
0.439
|
1.314 (0.657–2.625)
|
0.804
|
0.924 (0.496–1.721)
|
0.338
|
0.704 (0.342–1.448)
|
|
Allele
|
|
T
|
319 (66.7)
|
202 (71.6)
|
246 (65.8)
|
Ref.
| |
Ref.
| |
Ref.
| |
|
C
|
159 (33.3)
|
80 (28.4)
|
128 (34.2)
|
0.160
|
1.259 (0.913–1.735)
|
0.768
|
1.044 (0.784–1.390)
|
0.111
|
0.761 (0.544–1.065)
|
|
rs1053005
|
|
Genotype
|
|
AA
|
110 (46.0)
|
78 (55.3)
|
83 (44.4)
|
Ref.
| |
Ref.
| |
Ref.
| |
|
AG
|
104 (43.5)
|
51 (36.2)
|
84 (44.9)
|
0.102
|
1.446 (0.928–2.252)
|
0.742
|
0.934 (0.623–1.400)
|
0.065
|
0.646 (0.406–1.029)
|
|
GG
|
25 (10.5)
|
12 (8.5)
|
20 (10.7)
|
0.304
|
1.477 (0.700–3.118)
|
0.861
|
0.943 (0.491–1.813)
|
0.257
|
0.638 (0.293–1.392)
|
|
Allele
|
|
A
|
324 (67.8)
|
207 (73.4)
|
250 (66.8)
|
Ref.
| |
Ref.
| |
Ref.
| |
|
G
|
154 (32.2)
|
75 (26.6)
|
124 (33.2)
|
0.103
|
1.312 (0.946–1.818)
|
0.772
|
0.958 (0.718–1.279)
|
0.070
|
1.369 (0.974–1.925)
|
|
Haplotype (rs1053004-rs1053005)
|
|
T-A
|
319 (66.7)
|
202 (71.6)
|
246 (65.8)
|
Ref.
| |
Ref.
| |
Ref.
| |
|
C-G
|
154 (32.2)
|
75 (26.6)
|
124 (33.2)
|
0.116
|
1.300 (0.937–1.804)
|
0.770
|
1.044 (0.782–1.394)
|
0.079
|
1.358 (0.965–1.911)
|
|
T-G
|
0 (0)
|
0 (0)
|
4 (1.8)
|
1.000
|
1.000 (1.000–1.000)
|
0.023a
|
0.435 (0.396–0.478)
|
0.025b
|
0.549 (0.505–0.597)
|
|
C-A
|
5 (1.2)
|
5 (1.0)
|
0 (0)
|
0.471
|
1.579 (0.452–5.523)
|
0.050c
|
1.771 (1.647–1.904)
|
0.014d
|
2.218 (2.002–2.456)
|
- Data are presented as n (%). CH chronic hepatitis, LC liver cirrhosis, HCC hepatocellular carcinoma, OR odds ratio, 95%CI 95% confidence interval, Ref. reference. a P value by Bonferroni correction = 0.069; bP value by Bonferroni correction = 0.075; cP value by Bonferroni correction = 0.150; dP value by Bonferroni correction = 0.042
