Fig. 3From: A novel compound heterozygous variant of the SLC12A3 gene in Gitelman syndrome pedigreePredicted topological localization of Na-Cl cotransporter (NCC) mutations. Schematic representation of NCC protein with the intercellular N- and C-terminal domains and with squares 1 to 12 indicating the 12 transmembrane segments.[9] Arrows indicate the position of the selected mutationsBack to article page