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Table 3 Correlation of Genetic Models with Risk of Developing NIHL

From: Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

SNP

Genotype

Case

 

Control

 

OR (95%CI)*

p/pbon †

  

n

%

n

%

  

rs11920109

TT

40

13.7

92

15.8

1

0.738/0.148

TC

153

52.4

297

50.9

1.182 (0.774, 1.806)

0.439/0.088

CC

99

33.9

194

33.3

1.141 (0.724, 1.800)

0.531/0.106

CC + TC

252

86.3

491

84.2

1.155 (0.736, 1.814)

0.443/0.089

TT + TC

193

66.1

389

66.7

1

 

CC

99

33.9

194

33.3

1.016 (0.745, 1.386)

0.920/0.184

TT/TC/CC

    

1.055 (0.850,1.309)

0.627/0.125

Allele C/T

    

1.039 (0.866, 1.246)

0.682/0.136

rs1485175

TT

103

35.5

169

29.1

1

0.029/0.006

TC

139

47.9

276

47.5

0.820 (0.593, 1.132)

0.227/0.045

CC

48

16.6

136

23.4

0.564(0.370, 0.860)

0.008/0.002

CC + TC

187

64.5

412

70.9

0.737 (0.544, 1.000)

0.050/0.010

TT + TC

242

83.4

445

76.6

1

 

CC

48

16.6

136

23.4

0.636 (0.437, 0.925)

0.018/0.004

TT/TC/CC

    

0.761 (0.620, 0.934)

0.009/0.002

Allele C/T

    

0.800 (0.666, 0.962)

0.017/0.003

rs9819783

TT

38

13.1

86

14.8

1

0.785/0.157

TC

148

50.9

288

49.5

1.163 (0.753, 1.797)

0.496/0.099

CC

105

36.1

208

35.7

1.150 (0.728, 1.816)

0.550/0.110

CC + TC

253

86.9

496

85.2

1.158 (0.765, 1.752)

0.489/0.098

TT + TC

186

63.9

374

64.3

1

 

CC

105

36.1

208

35.7

1.024 (0.751, 1.396)

0.881/0.176

TT/TC/CC

    

1.054 (0.848, 1.309)

0.637/0.127

Allele C/T

    

1.038 (0.864, 1.248)

0.688/0.138

rs9826579

CC

8

2.7

16

2.7

1

0.718/0.144

CT

73

25.1

162

27.8

0.938 (0.369, 2.386)

0.893/0.179

TT

210

72.2

404

69.4

1.072 (0.438, 2.622)

0.879/0.176

TT + CT

283

97.3

566

97.3

1.049 (0430, 2.559)

0.917/0.183

CC + CT

81

27.8

178

30.6

1

 

TT

210

72.2

404

69.4

1.136 (0.833, 1.549)

0.422/0.084

CC/CT/TT

    

1.106 (0.844, 1.451)

0.465/0.093

Allele T/C

    

1.086 (0.849, 1.390)

0.510/0.102

rs9877154

TT

41

14.0

86

14.7

1

0.712/0.142

TC

147

50.3

278

47.6

1.125 (0.737, 1.719)

0.585/0.117

CC

104

35.6

220

37.7

0.995 (0.636, 1.556)

0.983/0.197

CC + TC

251

86.0

498

85.3

1.071 (0.715, 1.604)

0.740/0.148

TT + TC

188

64.4

364

62.3

1

 

CC

104

35.6

220

37.7

0.909 (0.670, 1.233)

0.539/0.108

TT/TC/CC

    

0.973 (0.787, 1.202)

0.799/0.160

Allele C/T

    

0.980 (0.815, 1.177)

0.825/0.165

  1. Effects of genetic models evaluated by conditional logistic regression
  2. *CNE, height, smoking, drinking, and hypertension are adjusted; CI: Confidence interval
  3. †Bonferroni correction is used to adjust p values by means of 0.05 / 5 (5 selected SNPs) to get pbon values of 0.01, which means that it is significant in statistics if pbon < 0.01
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BMC Medical Genetics

ISSN: 1471-2350

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