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Table 3 Correlation of Genetic Models with Risk of Developing NIHL

From: Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

SNP Genotype Case   Control   OR (95%CI)* p/pbon
   n % n %   
rs11920109 TT 40 13.7 92 15.8 1 0.738/0.148
TC 153 52.4 297 50.9 1.182 (0.774, 1.806) 0.439/0.088
CC 99 33.9 194 33.3 1.141 (0.724, 1.800) 0.531/0.106
CC + TC 252 86.3 491 84.2 1.155 (0.736, 1.814) 0.443/0.089
TT + TC 193 66.1 389 66.7 1  
CC 99 33.9 194 33.3 1.016 (0.745, 1.386) 0.920/0.184
TT/TC/CC      1.055 (0.850,1.309) 0.627/0.125
Allele C/T      1.039 (0.866, 1.246) 0.682/0.136
rs1485175 TT 103 35.5 169 29.1 1 0.029/0.006
TC 139 47.9 276 47.5 0.820 (0.593, 1.132) 0.227/0.045
CC 48 16.6 136 23.4 0.564(0.370, 0.860) 0.008/0.002
CC + TC 187 64.5 412 70.9 0.737 (0.544, 1.000) 0.050/0.010
TT + TC 242 83.4 445 76.6 1  
CC 48 16.6 136 23.4 0.636 (0.437, 0.925) 0.018/0.004
TT/TC/CC      0.761 (0.620, 0.934) 0.009/0.002
Allele C/T      0.800 (0.666, 0.962) 0.017/0.003
rs9819783 TT 38 13.1 86 14.8 1 0.785/0.157
TC 148 50.9 288 49.5 1.163 (0.753, 1.797) 0.496/0.099
CC 105 36.1 208 35.7 1.150 (0.728, 1.816) 0.550/0.110
CC + TC 253 86.9 496 85.2 1.158 (0.765, 1.752) 0.489/0.098
TT + TC 186 63.9 374 64.3 1  
CC 105 36.1 208 35.7 1.024 (0.751, 1.396) 0.881/0.176
TT/TC/CC      1.054 (0.848, 1.309) 0.637/0.127
Allele C/T      1.038 (0.864, 1.248) 0.688/0.138
rs9826579 CC 8 2.7 16 2.7 1 0.718/0.144
CT 73 25.1 162 27.8 0.938 (0.369, 2.386) 0.893/0.179
TT 210 72.2 404 69.4 1.072 (0.438, 2.622) 0.879/0.176
TT + CT 283 97.3 566 97.3 1.049 (0430, 2.559) 0.917/0.183
CC + CT 81 27.8 178 30.6 1  
TT 210 72.2 404 69.4 1.136 (0.833, 1.549) 0.422/0.084
CC/CT/TT      1.106 (0.844, 1.451) 0.465/0.093
Allele T/C      1.086 (0.849, 1.390) 0.510/0.102
rs9877154 TT 41 14.0 86 14.7 1 0.712/0.142
TC 147 50.3 278 47.6 1.125 (0.737, 1.719) 0.585/0.117
CC 104 35.6 220 37.7 0.995 (0.636, 1.556) 0.983/0.197
CC + TC 251 86.0 498 85.3 1.071 (0.715, 1.604) 0.740/0.148
TT + TC 188 64.4 364 62.3 1  
CC 104 35.6 220 37.7 0.909 (0.670, 1.233) 0.539/0.108
TT/TC/CC      0.973 (0.787, 1.202) 0.799/0.160
Allele C/T      0.980 (0.815, 1.177) 0.825/0.165
  1. Effects of genetic models evaluated by conditional logistic regression
  2. *CNE, height, smoking, drinking, and hypertension are adjusted; CI: Confidence interval
  3. Bonferroni correction is used to adjust p values by means of 0.05 / 5 (5 selected SNPs) to get pbon values of 0.01, which means that it is significant in statistics if pbon < 0.01