The (FTO) gene polymorphism is associated with metabolic syndrome risk in Egyptian females: a case- control study

Table 1 Characteristics of MetS cases (n = 92) and controls (n = 105)

Characteristic	MetS cases (n = 92)	Controls (n = 105)	p
Age, years, mean ± S.D	45.33 ± 9.56	44.74 ± 9.67	0.672^c
BMI, Kg/m², mean ± S.D	37.64 ± 5.7	26.07 ± 5.4	<0.001 ^a
Waist (cm),mean ± S.D	119.76 ± 10.96	89.68 ± 13.87	<0.001 ^a
TC (mg/dl), mean ± S.D	182.12 ± 44.52	165.42 ± 22.74	0.001 ^a
TAG (mg/dl), mean ± S.D	177.45 ± 84.06	110.06 ± 33.25	<0.001 ^a
HDL-C (mg/dl), mean ± S.D	38.51 ± 9.33	44.76 ± 8.07	<0.001 ^a
LDL-C (mg/dl), mean ± S.D	108.11 ± 39.44	98.58 ± 20.31	0.038 ^a
FPG (mg/dl), median(min-max)	161(64-361)	89(60-323)	<0.001 ^b
FSI(μIU/mL), median(min-max)	13.39(2.9–30.3)	8.5(1-30)	<0.001 ^b
HOMA-IR, median(min-max)	4.48(0.77–20.46)	1.9(0.2-23.93)	<0.001 ^b
QUICKI, mean ± S.D	0.31 ± 0.04	0.35 ± 0.05	<0.001 ^a
FTO (rs9939609)
TT, n(%)	24 (26.1)	43 (41)
AT, n(%)	50 (54.4)	54 (51.4)
AA, n(%)	18 (19.5)	8 (7.6)	0.014 ^c

Values are mean ± SD for parametric variables or median (range) for non-parametric variables. BMI Body mass index, WC Waist circumference, T.C Total cholesterol, TAG Triacylglycerol, HDL-C High density lipoprotein-cholesterol, LDL-C Low density lipoprotein-cholesterol, FPG Fasting plasma glucose, FSI Fasting serum insulin
^aIndependent T- test, two-sided p value >0.05 non-significant
^bMann–Whitney U test, two sided p value >0.05 non-significant
^cChi-square test, two-sided p value >0.05 non-significant

ISSN: 1471-2350