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Table 5 Stratification analyses of genetic susceptibility of FSHR rs6165, rs6166, rs1394205 polymorphisms to male infertility

From: The susceptibility of FSHB -211G > T and FSHR G-29A, 919A > G, 2039A > G polymorphisms to men infertility: an association study and meta-analysis

Variables

Cases/controls

GG vs. AA

AG vs. AA

AG + GG vs. AA

GG vs. AA + AG

Rs6165

 

OR (95% CI)

P

P h

I 2

OR (95% CI)

P

P h

I 2

OR (95% CI)

P

P h

I 2

OR (95% CI)

P

P h

I 2

Total

2564/2903

1.11 (0.94–1.31)

0.218

0.107

35.4%

1.15 (1.02–1.30)

0.021

0.084

38.6%

1.15 (0.98–1.34) b

0.092

0.042

45.6%

1.03 (0.89–1.20)

0.685

0.277

17.0%

HWE

  > 0.05

1999/2135

1.26 (1.03–1.54)

0.023

0.434

0

1.18 (1.03–1.36)

0.018

0.178

30.0%

1.20 (1.05–1.37)

0.006

0.190

28.7%

1.17 (0.98–1.41)

0.091

0.522

0

Race

 Caucasian

1290/1367

1.05 (0.84–1.30)

0.684

0.085

48.3%

1.09 (0.91–1.30)

0.342

0.122

42.5%

1.08 (0.92–1.28)

0.358

0.059

53.0%

1.02 (0.85–1.24)

0.820

0.146

39.0%

 Asian

1136/1319

1.17 (0.88–1.55)

0.279

0.166

38.3%

1.16 (0.97–1.38)

0.107

0.209

31.8%

1.16 (0.98–1.37)

0.086

0.139

42.5%

1.08 (0.82–1.41)

0.597

0.302

17.6%

 Brazilian

138/217

1.37 (0.76–2.49)

0.301

-

 

1.81 (1.08–3.31)

0.023

-

 

1.65 (1.02–2.67)

0.042

-

 

0.95 (0.58–1.56)

0.836

-

 

Case count

  > 200

1778/1637

1.20 (0.88–1.65) b

0.254

0.038

55.1%

1.17 (1.00–1.36)

0.047

0.112

41.9%

1.17 (0.94–1.45) b

0.163

0.044

53.7%

1.08 (0.91–1.30)

0.380

0.092

44.8%

  < 200

786/1266

1.02 (0.77–1.35)

0.913

0.525

0

1.13 (0.93–1.38)

0.222

0.111

46.8%

1.10 (0.91–1.32)

0.329

0.140

42.2%

0.93 (0.72–1.21)

0.591

0.810

0

Rs6166

 

GG vs. AA

   

AG vs. AA

   

AG + GG vs. AA

   

GG vs. AA + AG

   

Total

3728/4320

1.12 (0.98–1.29)

0.099

0.263

16.6%

1.07 (0.97–1.18)

0.205

0.514

0

1.08 (0.98–1.19)

0.121

0.300

13.4%

1.07 (0.94–1.20)

0.306

0.325

11.2%

HWE

  > 0.05

2893/3312

1.24 (1.05–1.45)

0.009

0.395

5.1%

1.06 (0.95–1.19)

0.307

0.331

11.7%

1.10 (0.99–1.22)

0.077

0.192

25.6%

1.20 (1.04–1.39)

0.013

0.738

0

Race

 Caucasian

2454/2784

1.11 (0.94–1.30)

0.218

0.307

14.7%

1.07 (0.95–1.22)

0.267

0.328

12.5%

1.08 (0.96–1.21)

0.204

0.208

25.6%

1.06 (0.92–1.23)

0.403

0.456

0

 Asian

1136/1319

1.29 (0.97–1.73)

0.085

0.292

19.2%

1.05 (0.88–1.25)

0.614

0.442

0

1.09 (0.92–1.29)

0.324

0.284

20.5%

1.27 (0.96–1.68)

0.099

0.479

0

 Brazilian

138/217

0.77 (0.43–1.38)

0.371

-

 

1.15 (0.66–1.99)

0.621

-

 

0.97 (0.58–1.61)

0.894

-

 

0.70 (0.44–1.12)

0.127

-

 

Case count

  > 200

2786/2929

1.18 (1.00–1.38)

0.047

0.241

22.7%

1.10 (0.98–1.24)

0.111

0.452

0

1.11 (0.99–1.24)

0.054

0.319

13.8%

1.11 (0.96–1.28)

0.168

0.242

22.6%

  < 200

942/1391

0.99 (0.77–1.29)

0.931

0.376

6.7%

0.99 (0.82–1.19)

0.888

0.495

0

0.99 (0.83–1.18)

0.891

0.348

10.7%

0.97 (0.77–1.22)

0.777

0.459

0

Rs1394205

 

AA vs. GG

   

AG vs. GG

   

AA + AG vs. GG

   

AA vs. GG + AG

   

Total

2048/2776

0.90 (0.63–1.28) b

0.541

0.022

59.4%

0.91 (0.71–1.15)b

0.422

0.004

68.9%

0.91 (0.71–1. 17)b

0.468

0.001

74.4%

0.93 (0.77–1.12)

0.440

0.394

4.3%

HWE

  > 0.05

1563/2185

0.89 (0.56–1.44) b

0.643

0.006

72.3%

0.89 (0.64–1.24)b

0.489

0.001

68.9%

0.90 (0.63–1.27) b

0.543

0.000

82.6%

0.92 (0.75–1.14)

0.440

0.181

36.0%

Race

 Caucasian

1617/1967

0.93 (0.70–1.23)

0.612

0.383

4.1%

0.98 (0.85–1.14)

0.832

0.698

0

0.97 (0.85–1.12)

0.708

0.453

0

0.93 (0.71–1.23)

0.622

0.524

0

 Asian

431/809

0.73 (0.27–1.98)b

0.537

0.002

89.3%

0.70 (0.29–1.66)b

0.412

0.001

90.1%

0.71 (0.28–1.77)b

0.458

0.000

92.1%

0.92 (0.71–1.21)

0.550

0.080

67.4%

Case count

  > 200

1722/2099

0.99 (0.77–1.26)

0.903

0.294

19.0%

0.99 (0.86–1.15)

0.930

0.661

0

0.99 (0.86–1.13)

0.836

0.388

3.2%

0.99 (0.79–1.25)

0.958

0.430

0

  < 200

326/677

0.68 (0.26–1.79) b

0.430

0.043

75.5%

0.67 (0.30–1.48)b

0.319

0.005

87.5%

0.67 (0.30–1.54) b

0.347

0.002

89.5%

0.78 (0.54–1.12)

0.176

0.268

18.4%

  1. a P value of Q-test heterogeneity test
  2. bRandom-effect model was used when a PH < 0.05, otherwise, fixed-effects model was used; Bold numbers mean statistically significant results
  3. OR odds ratio, CI confidence interval, P H P value of heterogeneity, I 2 :0–25 no heterogeneity, 20–50 modest
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BMC Medical Genetics

ISSN: 1471-2350

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