Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis

Table 3 Association testing between NOS1AP rs12143842 and QTc, stratified by genotype and sex, in two LQT1 founder populations

Study population	N	AA N	AA QTc^a	Aa/aa N	Aa/aa QTc^a	Effect^b	P^c
All participants	312	150	458 ± 35	162	469 ± 40	+11 (4)	0.011
All genotype positive	227	109	470 ± 33	118	481 ± 37	+12 (5)	0.013
All Y111C	148	73	476 ± 29	75	489 ± 33	+13 (6)	0.014
All R518^a	79	36	457 ± 36	43	467 ± 32	+10 (8)	0.211
All genotype negative	85	41	428 ± 23	44	437 ± 25	+9 (5)	0.090
All females	180	82	470 ± 32	98	473 ± 37	+4 (5)	0.458
Genotype positive females	133	62	480 ± 28	71	486 ± 31	+6 (5)	0.244
Y111C females	84	39	484 ± 25	45	493 ± 28	+9 (6)	0.122
R518^a females	49	23	473 ± 34	26	474 ± 35	+1 (10)	0.926
Genotype negative females	47	20	437 ± 21	27	440 ± 28	+3 (7)	0.702
All males	132	68	445 ± 35	64	463 ± 43	+18 (7)	0.009
Genotype positive males	94	47	456 ± 33	47	474 ± 44	+18 (8)	0.028
Y111C males	64	34	467 ± 31	30	485 ± 49	+18 (10)	0.080
R518^a males	30	13	428 ± 23	17	456 ± 26	+27 (9)	0.007
Genotype negative males	38	21	419 ± 21	17	431 ± 18	+12 (7)	0.060

AA- ancestral rs12143842 genotype, Aa/aa- carrier of one or two derived/minor rs12143842 alleles, respectively
^aManually measured on 12-lead resting electrocardiograms and heart rate corrected using Bazett’s formula, in ms
^bThe effect on QTc, in ms, if having one or more rs12143842 minor alleles (a), as compared to ancestral genotype (AA), i.e. unstandardized beta coefficient, followed by standard error in parenthesis
^cAs calculated by linear single covariate regression analysis (in bold when significant at the <0.05 level)

ISSN: 1471-2350