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Table 3 Association testing between NOS1AP rs12143842 and QTc, stratified by genotype and sex, in two LQT1 founder populations

From: Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis

Study population N AA N AA QTca Aa/aa N Aa/aa QTca Effectb Pc
All participants 312 150 458 ± 35 162 469 ± 40 +11 (4) 0.011
All genotype positive 227 109 470 ± 33 118 481 ± 37 +12 (5) 0.013
 All Y111C 148 73 476 ± 29 75 489 ± 33 +13 (6) 0.014
 All R518a 79 36 457 ± 36 43 467 ± 32 +10 (8) 0.211
All genotype negative 85 41 428 ± 23 44 437 ± 25 +9 (5) 0.090
All females 180 82 470 ± 32 98 473 ± 37 +4 (5) 0.458
Genotype positive females 133 62 480 ± 28 71 486 ± 31 +6 (5) 0.244
 Y111C females 84 39 484 ± 25 45 493 ± 28 +9 (6) 0.122
 R518a females 49 23 473 ± 34 26 474 ± 35 +1 (10) 0.926
Genotype negative females 47 20 437 ± 21 27 440 ± 28 +3 (7) 0.702
All males 132 68 445 ± 35 64 463 ± 43 +18 (7) 0.009
Genotype positive males 94 47 456 ± 33 47 474 ± 44 +18 (8) 0.028
 Y111C males 64 34 467 ± 31 30 485 ± 49 +18 (10) 0.080
 R518a males 30 13 428 ± 23 17 456 ± 26 +27 (9) 0.007
Genotype negative males 38 21 419 ± 21 17 431 ± 18 +12 (7) 0.060
  1. AA- ancestral rs12143842 genotype, Aa/aa- carrier of one or two derived/minor rs12143842 alleles, respectively
  2. aManually measured on 12-lead resting electrocardiograms and heart rate corrected using Bazett’s formula, in ms
  3. bThe effect on QTc, in ms, if having one or more rs12143842 minor alleles (a), as compared to ancestral genotype (AA), i.e. unstandardized beta coefficient, followed by standard error in parenthesis
  4. cAs calculated by linear single covariate regression analysis (in bold when significant at the <0.05 level)