Fig. 4

A schematic representation of 5 TCF7L2 non-coding SNPs in the gene structure. The start and stop codons are indicated by “ATG” (in exon 1) and “STOP” (in exons 15, 16, and 17), respectively. Because of alternative splicing, 3 groups of protein isoforms (i.e., short-, medium-, and large-length isoforms) can be generated by using different stop codons, which are indicated by “Short”, “Medium”, and “Long”, respectively