Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction

Table 3 Associations between TBR1 genotype, MSDP and measures of offspring antisocial behaviour

TBR1 genotype		MSDP
TBR1 genotype		No	Yes
(a) Childhood conduct problems (7–9 years)
Homozygous major allele	Mean (SD)	98.5 (8.4)	99.4 (8.6)
Homozygous major allele	N	312	140
Other	Mean (SD)	99.2 (9.0)	107.6 (13.2)
Other	N	79	39
Fitted regression model: main effect TBR1 (B = 0.71, SE = 1.12, p = 0.53); main effect MSDP (B = 0.93, SE = 0.91, p = 0.31); TBR1 x MSDP interaction (B = 7.51, SE = 1.97, p < 0.001)
(b) Adolescent conduct problems (15–16 years)
Homozygous major allele	Mean (SD)	98.6 (8.8)	100.7 (10.5)
Homozygous major allele	N	300	136
Other	Mean (SD)	97.8 (6.8)	107.5 (14.1)
Other	N	75	39
Fitted regression model: main effect TBR1 (B = -0.85, SE = 1.22, p = 0.49); main effect MSDP (B = 2.04, SE = 0.98, p = 0.04); TBR1 x MSDP interaction (B = 7.70, SE = 2.11, p < 0.001)
(c) Self-reported property/violent offences (14–25 years)
Homozygous major allele	Mean (SD)	9.2 (35.0)	15.1 (52.6)
Homozygous major allele	N	303	139
Other	Mean (SD)	5.8 (15.3)	26.9 (83.6)
Other	N	78	36
Fitted regression model: main effect TBR1 (B =−0.46, SE = 0.34, p = 0.18); main effect MSDP (B = 0.50, SE = 0.20, p = 0.01); TBR1 x MSDP interaction (B = 1.03, SE = 0.43, p = 0.02)
(d) Self-reported arrests or convictions (16–25 years)
Homozygous major allele	Mean (SD)	0.6 (2.1)	1.3 (4.5)
Homozygous major allele	N	303	139
Other	Mean (SD)	0.3 (0.8)	2.0 (5.4)
Other	N	78	36
Fitted regression model: main effect TBR1 (B = −0.83, SE = 0.44, p = 0.06); main effect MSDP (B = 0.78, SE = 0.20, p < 0.001); TBR1 x MSDP interaction (B = 1.27, SE = 0.51, p = 0.01)

ISSN: 1471-2350