|
SNP
|
Trait
|
Chr
|
Major/Major
|
Major/Minor
|
Minor/Minor
|
Direction of Changea
|
|---|
|
rs2033711
|
UACl
|
19
|
2.17 ± 1.79
|
2.79 ± 2.19
|
3.48 ± 2.69
|
↑
|
|
rs10908521
|
UACl
|
1
|
2.86 ± 2.28
|
2.06 ± 1.66
|
1.86 ± 1.34
|
↓
|
|
rs10423138
|
UACl
|
19
|
2.18 ± 1.78
|
2.77 ± 2.17
|
3.38 ± 2.68
|
↑
|
|
rs9874872
|
UrUA/UrCr
|
3
|
0.18 ± 0.12
|
0.13 ± 0.10
|
0.11 ± 0.08
|
↓
|
|
rs1353327
|
UrUA/UrCr
|
3
|
0.17 ± 0.11
|
0.11 ± 0.09
|
0.14 ± 0.13
|
↓
|
|
rs17079585
|
CrCl
|
13
|
54.26 ± 32.25
|
22.47 ± 14.47
|
-
|
↓
|
|
rs4889855
|
FEUA
|
17
|
7.22 ± 6.01
|
5.88 ± 5.74
|
4.34 ± 3.76
|
↓
|
|
rs17079585
|
GLUA
|
13
|
3.02 ± 2.28
|
1.28 ± 0.77
|
-
|
↓
|
-
aDirection of associations for minor alleles of the SNPs in the genes associated with renal handling measures from GWAS; Chr chromosome, UACl uric acid clearance, UrUA/UrCr urinary uric acid to urinary creatinine ratio, CrCl creatinine clearance, FEUA fractional excretion of uric acid, GLUA glomerular load of uric acid
