|
Variable
|
Boys (N = 397)
|
Girls (N = 371)
|
Total (N = 768)
|
Heritability estimates
|
|---|
|
Mean ± SD
|
Mean ± SD
|
Mean ± SD
|
h2 ± SE
|
P value
|
|---|
|
Age, years
|
11.88 ± 3.24
|
12.02 ± 3.48
|
11.95 ± 3.36
|
-
|
-
|
|
BSA, m2
|
1.55 ± 0.40*
|
1.47 ± 0.33*
|
1.51 ± 0.37
|
-
|
-
|
|
BSAZ
|
0.33 ± 0.91*
|
0.14 ± 0.76*
|
0.24 ± 0.85
|
-
|
-
|
|
UrCr, mg/dL
|
95.37 ± 39.53
|
83.86 ± 32.10
|
89.81 ± 36.57
|
0.41 ± 0.10
|
1.9 × 10−06
|
|
CrCl, ml/min
|
60.59 ± 35.11*
|
47.41 ± 26.20*
|
54.22 ± 31.80
|
0.52 ± 0.09
|
2.5 × 10−10
|
|
SUA, mg/dL
|
5.84 ± 1.76*
|
4.99 ± 1.43*
|
5.43 ± 1.66
|
0.63 ± 0.09
|
1.4 × 10−12
|
|
UrUA, mg/dL
|
15.63 ± 13.19*
|
13.43 ± 11.41*
|
14.57 ± 12.40
|
0.70 ± 0.05
|
1.1 × 10−24
|
|
UACl, ml/min
|
2.99 ± 2.31*
|
2.43 ± 1.96*
|
2.72 ± 2.17
|
0.65 ± 0.06
|
1.7 × 10−20
|
|
UrUA/UrCr
|
0.17 ± 0.11*
|
0.16 ± 0.11*
|
0.16 ± 0.11
|
0.73 ± 0.05
|
1.3 × 10−25
|
|
FEUA, %
|
6.02 ± 5.14
|
6.34 ± 6.02
|
6.17 ± 5.58
|
0.74 ± 0.05
|
6.7 × 10−27
|
|
GLUA, mg/min/m2
|
3.63 ± 2.64*
|
2.33 ± 1.46*
|
3.00 ± 2.25
|
0.57 ± 0.09
|
2.2 × 10−11
|
|
EUAGF, mg/dL/m2
|
0.33 ± 0.30
|
0.30 ± 0.31
|
0.32 ± 0.31
|
0.73 ± 0.05
|
6.1 × 10−25
|
- *p-value is significantly different at <0.05 between boys and girls; BSA body surface area, BSAZ body surface area z-scores, UrCr urinary creatinine, SUA serum uric acid, UrUA urinary uric acid, UACl uric acid clearance, UrUA/UrCr urinary uric acid to urinary creatinine ratio, FEUA fractional excretion of uric acid, GLUA glomerular load of uric acid, EUAGF excretion of uric acid per volume of glomerular filtration. All traits for heritability analyses adjusted for age, sex, age*sex, age^2, age^2*sex, body surface area z-scores; p-value <0.05 considered statistically significant
