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Table 2 Allele Frequencies for the variants studied

From: Genetic causes of Parkinson’s disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR

Mutation/polymorphism

Allele frequencies in %

 

Controls (n mutant/total n)a

Cases (n mutant/total n)a

QDPR c.68G > A

0.3 (2/612)

0.3 (1/300)

SPR c.596-2A > G

0.7 (4/594)

0.0 (0/296)

MTHFR c.677C > T

34.7 (216/622)

33.8 (102/302)

MTHFR c.1298A > C

35.9 (225/626)

37.7 (114/302)

Tested in cases only

  LRRK2 c.6055G > A

-

1.4 (4/292)

  LRRK2 c.4321C > G

-

0.0 (0/296)

  SNCA c.209G > A

-

0.0 (0/292)

  1. n = number of alleles
  2. aDNA of 79 controls and 27 cases had been used up and were therefore not available and a few samples did not yield PCR products
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BMC Medical Genetics

ISSN: 1471-2350

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