The role of mitochondrial genomics in patients with non-alcoholic steatohepatitis (NASH)

BMC Medical Genetics

Table 2 Comparisons of Controls (normal liver histology) with Non-NASH NAFLD and NASH

Variable	Normal liver histology (N = 94)	Non-NASH NAFLD (N = 143)	NASH (N = 104)	P-value*	P-value†	P-value‡
Age (yrs)	41.48 ± 10.86	44.08 ± 11.39	46.42 ± 10.94	0.0814	0.0017	0.1053
BMI (kg/m²)	46.80 ± 7.98	47.80 ± 8.50	49.47 ± 10.56	0.3733	0.0512	0.1715
WBC (x 10³/uL)	7.81 ± 2.54	8.08 ± 2.21	8.82 ± 8.81	0.3784	0.2855	0.3366
Platelets (x 10³/uL)	303.51 ± 69.73	291.01 ± 64.23	268.69 ± 66.97	0.1632	0.0005	0.0094
Insulin Resistance	1.92 ± 2.83	2.40 ± 1.18	8.37 ± 11.00	0.4879	0.0413	0.0154
Glucose (mg/dL)	94.16 ± 21.74	110.47 ± 36.20	120.22 ± 43.50	0.0002	<.0001	0.0641
ALT (U/L)	22.20 ± 9.74	31.58 ± 16.35	49.51 ± 37.25	<.0001	<.0001	<.0001
AST (U/L)	19.41 ± 5.57	23.49 ± 11.04	36.43 ± 29.69	0.0013	<.0001	<.0001
Triglycerides (mg/dL)	125.84 ± 58.42	160.26 ± 87.31	182.10 ± 117.04	0.0018	0.0001	0.1152
LDL (mg/dL)	100.96 ± 35.75	110.75 ± 35.40	111.71 ± 36.34	0.0620	0.0646	0.8555
Total cholesterol (mg/dL)	175.84 ± 34.00	193.24 ± 39.40	190.10 ± 41.96	0.0011	0.0150	0.5683
HDL (mg/dL)	50.40 ± 12.42	48.58 ± 13.63	42.68 ± 10.96	0.3461	<.0001	0.0014
White: N (%)	66 (70.2 %)	112 (78.3 %)	84 (80.8 %)	0.1579	0.0835	0.6389
Diabetes: N (%)	17 (18.3 %)	44 (30.8 %)	46 (44.2 %)	0.0322	<.0001	0.030
Hyperlipidemia: N (%)	34 (37.4 %)	69 (50.0 %)	59 (59.6 %)	0.0599	0.0022	0.1438
Hypertension: N (%)	40 (44.4 %)	81 (57.9 %)	64 (65.3 %)	0.0468	0.0041	0.2464
Sleep Apnea: N (%)	53 (57.6 %)	100 (71.9 %)	81 (80.2 %)	0.0241	0.0007	0.1425

*Pairwise comparison between controls (normal liver histology) and Non-NASH NAFLD cohorts; †Pairwise comparison between controls (normal liver histology) and NASH cohorts; ‡Pairwise comparison between Non-NASH NAFLD and NASH cohorts. Continuous variables are represented as mean ± standard deviation (SD), and categorical variables as percentages. For convenience, all statistically significant p-values are highlighted by bold font

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