Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity

Table 5 Regression analysis comparing CT/TT carriers of MONET to CAO in women with overweight or obesity

Multiple regression model	Dependent variable	Number of subjects (n)	Parameter estimate	Standard error	Variable p-value	R²	R² (adjusted)	Model p-value
1	∆ BMI	123	0.36	1.50	0.812	0.130	0.069	0.038
2	∆ Lean Mass	124	−0.35	1.39	0.802	0.212	0.150	0.001
3	∆ Fat Mass	121	2.15	2.92	0.462	0.233	0.170	<0.001
4	∆ % Lean Mass	126	−1.10	1.68	0.513	0.268	0.212	<0.001
5	∆ % Fat Mass	121	1.73	1.89	0.361	0.315	0.252	<0.001
6	∆ Visceral Fat	124	1.28	4.97	0.798	0.155	0.096	0.011
7	∆ Muscle attenuation	128	0.58	0.95	0.543	0.134	0.091	0.007

* Multiple linear regression analysis was conducted. Independent variables included three dummy variables to identify the polymorphism group (CC CAO, CC MONET and CT/TT CAO) with the exception of CT/TT MONET while adjusting for covariables determined by best subset multiple linear regression, independent for each model (Table 1). Following results illustrate parameter estimates, standard error, p-values corresponding to CT/TT CAO independent variable

ISSN: 1471-2350