Analysis of association among clinical features and shorter leukocyte telomere length in mitochondrial diabetes with m.3243A>G mitochondrial DNA mutation

Table 3 Specific clinical features in mitochondrial diabetes (n = 15)

	Family member	Age at diagnosis (year)	BMI (kg/m2)	Autoimmune diabetes antibodies	Deafness	Fasting/postprandial elevated blood lactate	Encephalomyopathy	The peak height G/A ratio%
1	II1 (P:I)	68	18.4	ND	+	ND	-	5.9
2	II2	49	23.4	IAA (−)、ICA (−)、GAD (−)	+	ND	-	14
3	II4	48	16.8	IAA (−)、ICA (−)、GAD (−)	+	ND	-	14.9
4	III1	18	18.7	IAA (−)、ICA (−)、GAD (−)	+	-	-	83.3
5	I2 (P:II)	25	17.4	ND	+	ND	-	31.6
6	II1	31	21.2	ND	+	+	+	29.1
7	II2	43	20.1	ND	+	ND	-	8.2
8	II3	38	19	IAA (−)、ICA (−)、GAD (−)	+	ND	-	27.6
9	I2 (P:III)	43	18.4	ND	+	ND	-	8
10	II1	17	18.3	IAA (−)、ICA (−)、GAD (−)	+	ND	-	65
11	I2 (P:IV)	33	16.7	IAA (−)、ICA (−)、GAD (−)	+	-	-	29
12	II1	24	21.7	ND	+	+	+	27.1
13	II1 (P:V)	26	24.9	ND	+	ND	-	34.5
14	II2	46	19.1	ND	+	ND	-	15.2
15	III1	17	18.4	IAA (−)、ICA (−)、GAD (−)	+	ND	-	63.6

For the structure of the five- mitochondrial diabetes pedigree, see Fig. 1. P, I-V represent family I-V.;ND represents undetected;-, negative; +, positive. The peak height G/A ratio, m.3243A>G mitochondrial DNA mutation peak height G to A ratio

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