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Table 1 Clinical characteristics of our study cohort

From: Next-generation-sequencing-based identification of familial hypercholesterolemia-related mutations in subjects with increased LDL–C levels in a latvian population

Variable CAD POP P-value Total
n 42 50   92
Age, years ± SD (min-max) 60.0 ± 12.1 (41–89) 58.6 ± 9.7 (23–78) 0.0017 62.0 ± 11.4 (23–89)
Female gender, % 35.7 68.0 0.0023 52.2
CAD, % 100 2.0 <0.0001 46,7
MI, % 54.8 0.0 <0.0001 25,0
TC level, mmol/L ± SD (min-max) 7.9 ± 0.7 (6.7-10.1) 9.3 ± 1.6 (7.0-14.0) <0.0001 8.7 ± 1.5 (6.7-14.0)
LDL-C level, mmol/L ± SD (min-max) 5.6 ± 0.7 (4.1-7.2) 6.6 ± 1.1 (5.1-9.7) <0.0001 6.2 ± 1.0 (4.1-9.7)
LDL-C > 8.5 mmol/L,n 0 5 0.0238 5
LDL-C 6.5-8.4 mmol/L,n 7 18 0.0343 25
LDL-C 5.0-6.4 mmol/L,n 30 27 0.0855 57
LDL-C 4.0-4.9 mmol/L,n 5 0 0.0235 5
BMI, kg/m2 ± SD (min-max) 28.8 ± 4.6 (16.9-41.5) 28.0 ± 5.8 (16.9-42.6) 0.4647 28.3 ± 5.3 (16.9-42.6)
  1. CAD – coronary artery disease; MI – myocardial infarction; TC – total cholesterol; LDL-C – low density lipoprotein cholesterol; BMI – body mass index; For age, TC, LDL-C and BMI mean values, ± standard deviations (SD) are given as well as minimal and maximal values in brackets