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Table 1 Clinical characteristics of our study cohort

From: Next-generation-sequencing-based identification of familial hypercholesterolemia-related mutations in subjects with increased LDL–C levels in a latvian population

Variable

CAD

POP

P-value

Total

n

42

50

 

92

Age, years ± SD (min-max)

60.0 ± 12.1 (41–89)

58.6 ± 9.7 (23–78)

0.0017

62.0 ± 11.4 (23–89)

Female gender, %

35.7

68.0

0.0023

52.2

CAD, %

100

2.0

<0.0001

46,7

MI, %

54.8

0.0

<0.0001

25,0

TC level, mmol/L ± SD (min-max)

7.9 ± 0.7 (6.7-10.1)

9.3 ± 1.6 (7.0-14.0)

<0.0001

8.7 ± 1.5 (6.7-14.0)

LDL-C level, mmol/L ± SD (min-max)

5.6 ± 0.7 (4.1-7.2)

6.6 ± 1.1 (5.1-9.7)

<0.0001

6.2 ± 1.0 (4.1-9.7)

LDL-C > 8.5 mmol/L,n

0

5

0.0238

5

LDL-C 6.5-8.4 mmol/L,n

7

18

0.0343

25

LDL-C 5.0-6.4 mmol/L,n

30

27

0.0855

57

LDL-C 4.0-4.9 mmol/L,n

5

0

0.0235

5

BMI, kg/m2 ± SD (min-max)

28.8 ± 4.6 (16.9-41.5)

28.0 ± 5.8 (16.9-42.6)

0.4647

28.3 ± 5.3 (16.9-42.6)

  1. CAD – coronary artery disease; MI – myocardial infarction; TC – total cholesterol; LDL-C – low density lipoprotein cholesterol; BMI – body mass index; For age, TC, LDL-C and BMI mean values, ± standard deviations (SD) are given as well as minimal and maximal values in brackets