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Table 4 Association of NR3C2 haplotypes with decreased risk of preterm birth. Continuous haplotype with the most significant association presented here for haplotypes consisting of two, three, and four NR3C2 alleles

From: Two novel genetic variants in the mineralocorticoid receptor gene associated with spontaneous preterm birth

NR3C2 SNPs

Reference haplotype

Associated haplotype

Case frequency

Control frequency

Odds ratio

95 % CI

p-value

1-2

C-A

T-G

0.11

0.18

0.58

0.40-0.85

0.0048

2-3

A-T

G-T

0.16

0.24

0.66

0.48-0.92

0.0043

3-4

T-C

T-T

0.26

0.36

0.51

0.33-0.79

0.0020

1-2-3

C-A-T

T-G-T

0.12

0.18

0.45

0.27-0.76

0.0054

2-3-4

A-T-C

G-T-T

0.13

0.21

0.44

0.27-0.73

0.0027

ALL

C-A-T-C

T-G-T-T

0.09

0.16

0.41

0.23-0.73

0.0011

  1. Associated haplotypes were compared against all other haplotypes to determine significance. NR3C2 SNPs are enumerated 1–4 with the numbers representing rs17484063, rs2883929, rs4835136, and rs7680420, respectively
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BMC Medical Genetics

ISSN: 1471-2350

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