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Table 1 Summary of Kv4.3 WT and dupRVF mutant channel properties

From: First de novo KCND3 mutation causes severe Kv4.3 channel dysfunction leading to early onset cerebellar ataxia, intellectual disability, oral apraxia and epilepsy

Kv4.3 Current density at +83 mV (pA) Activation Inactivation
V1/2 (mV) Slope (mV) V1/2 (mV) Slope (mV)
WT (n = 8) 8561 ± 620 −13.3 ± 3.2 12.7 ± 0.8 −59.7 ± 6.1 4.7 ± 0.5
dupRVF (n = 9) 3861 ± 668** 46.0 ± 2.1** 11.7 ± 0.5 2.3 ± 7.0** 15.3 ± 2.0*
  1. Values are means ± SEM
  2. Statistical analysis t-test: *, p < 0.001; **, p < 0.0001