Table 1 a) Small intestinal biopsy and b) Peripheral blood gene expression vs. celiac disease status. Fold change and effect direction is presented for the celiac disease group (n = 167) with the control and potential celiac disease group (n = 235) set as reference. Individuals in the pilot data sets were excluded from the biopsy gene expression analysis. The analysis was adjusted for age and sex in both tissues
a. Small intestinal biopsy | |||
Gene symbol | Gene name | Fold (95 % CI) change | pc |
ADCY9 | Adenylate cyclase 9 | 2.2 (1.8-2.7) DOWN | 1.3E-13 |
APPL2 | Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 | 1.9 (1.7-2.1) DOWN | 1.9E-25 |
GLSa | Glutaminase | 2.0 (1.6-2.5) DOWN | 1.1E-08 |
HSPB1 | Heat shock 27 kDa protein 1 | 1.9 (1.5-2.3) DOWN | 5.9E-08 |
INSR | Insulin receptor | 2.1 (1.8-2.5) DOWN | 3.0E-18 |
KIF13A | Kinesin family member 13A | 1.5 (1.3-1.7) DOWN | 3.6E-05 |
NCALD | Neurocalcin delta | 1.4 (1.2-1.6) UP | 1.7E-04 |
NTS | Neurotensin | 3.6 (2.7-4.9) DOWN | 5.5E-15 |
PDK1 | Pyruvate dehydrogenase kinase, isozyme 1 | 1.3 (1.1-1.6) UP | 7.5E-03 |
PPP1R12Ba | Myosin light chain phosphatase catalytic subunit 12B | 1.9 (1.6-2.2) UP | 2.5E-12 |
PRR5L | Proline rich 5 like | 1.2 (1.1-1.4) UP | 3.6E-03 |
b. Peripheral blood | |||
Gene symbol | Gene name | Fold (95 % CI) change | p (pc) |
ADCY9 | Adenylate cyclase 9 | Low transcript quality | Low transcript quality |
APPL2 | Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 | 1.3 (1.1-1.5) DOWN | 0.003 (0.02) |
GLSa | Glutaminase | 1.1 (0.8-1.4) DOWN | 0.63 |
HSPB1 | Heat shock 27 kDa protein 1 | Low transcript quality | Low transcript quality |
INSR | Insulin receptor | 1.2 (1.0-1.4) DOWN | 0.088 |
KIF13A | Kinesin family member 13A | 1.3 (1.0-1.8) UP | 0.10 |
NCALD | Neurocalcin delta | 1.5 (1.1-2.0) UP | 0.008 (0.04) |
NTS | Neurotensin | Not expressed | Not expressed |
PDK1 | Pyruvate dehydrogenase kinase, isozyme 1 | Low transcript quality | Low transcript quality |
PPP1R12Ba | Myosin light chain phosphatase catalytic subunit 12B | Not expressed | Not expressed |
PRR5L | Proline rich 5 like | 1.3 (1.0-1.8) UP | 0.081 |