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Table 5 Association analyses between left ventricular mass indexed by height 2.7 and nine candidate SNPs from the HyperGEN study in the Korean population

From: Validation study of candidate single nucleotide polymorphisms associated with left ventricular hypertrophy in the Korean population

  

Log (LVM/height 2.7 )

LVH

SNP

LVM/height 2.7 , g/m 2.7

Beta§

L95

U95

P value

OR§

L95

U95

P value

rs409045

 

−0.024

−0.049

0.001

0.062

0.816

0.629

1.058

0.125

TT (n = 1239)

45.5 ± 12.0

        

CT + CC (n = 398)

45.2 ± 11.8

        

rs6450415

 

0.016

−0.007

0.039

0.178

1.320

1.041

1.673

0.022

TT (n = 1118)

45.3 ± 11.9

        

CT + CC (n = 519)

45.8 ± 11.9

        

rs6961069

 

0.002

−0.019

0.024

0.840

1.157

0.927

1.445

0.197

TT (n = 808)

45.4 ± 11.3

        

CT + CC (n = 829)

45.5 ± 12.5

        

rs10499859

 

0.002

−0.019

0.024

0.838

1.176

0.942

1.469

0.152

AA (n = 799)

45.3 ± 11.3

        

AG + GG (n = 838)

45.5 ± 12.5

        

rs4129218

 

−0.027

−0.048

−0.005

0.016

0.731

0.582

0.919

0.007

AA (n = 975)

46.1 ± 12.2

        

AG + GG (n = 662)

44.5 ± 11.5

        

rs1155635

 

−0.004

−0.027

0.019

0.717

0.873

0.690

1.106

0.261

AA (n = 543)

45.4 ± 11.6

        

GA + GG (n = 1081)

45.5 ± 12.1

        

rs2415872

 

−0.011

−0.033

0.010

0.293

0.937

0.750

1.171

0.569

GG (n = 735)

45.8 ± 12.0

        

GC + CC (n = 902)

45.1 ± 11.9

        

rs756529

 

0.014

−0.008

0.036

0.218

1.059

0.842

1.332

0.625

AA (n = 609)

44.8 ± 11.5

        

GA + GG (n = 1028)

45.8 ± 12.1

        

rs10483186

 

−0.005

−0.027

0.017

0.637

0.943

0.752

1.184

0.614

GG (n = 622)

45.7 ± 12.0

        

GT + TT (n = 1015)

45.3 ± 11.9

        
  1. §Analysis adjusted for age, gender, body mass index, serum creatinine, systolic blood pressure, heart rate and antihypertensive medication.
  2. Abbreviations: L95 and U95, confidence interval lower and upper 95%; LVH, left ventricular hypertrophy defined as LVM/ height2.7 ≥ 49 g/m2.7 in males and ≥ 45 g/m2.7 in females; LVM/height2.7, left ventricular mass indexed by height2.7; SNP, single nucleotide polymorphism.