Figure 1

Facial features in individuals withint22h-1/int22h-2-mediated Xq28 rearrangements. A: facial features of the proband in family 1, including high forehead, sparse eyebrows and scalp hair, long eyelashes, upper eyelid fullness, broad and depressed nasal bridge, anteverted nares, and long philtrum. B: facial features of the mother in family 1, including deep set eyes and thick lower lip. C: facial features of the youngest sister in family 5 including high forehead, full upper eyelid, broad nasal bridge, and thick lower lip. D: facial features of the middle sister in family 5 including high forehead, full upper eyelid, broad nasal bridge, and thick lower lip. E: facial features of the oldest sister in family 5 including high forehead, full upper eyelid, and thick lower lip. F: facial features of the mother in family 5 including high forehead, elongated face, full upper eyelid, and thick lower lip. G: facial features of the proband in family 6, including high forehead, deep-set eyes, epicanthus, and broad nasal bridge.