Table 4 Association between CYP2C19 genotype and risk of ESCC
Polymorphism. ID no | Genotypes | Cases n (%) | Controls n (%) | Crude OR (95% CI) | Adjusted OR (95% CI a ) | P -value a,b |
|---|---|---|---|---|---|---|
CYP2C19*2 | ||||||
rs4244285 | GG | 59 (20.70) | 243 (42.63) | 1.00 (Reference) | 1.00 (Reference) | 6.47 × 10-8 |
GA | 174 (61.05) | 272 (47.72) | 2.64 (1.87 ~ 3.71) | 2.91 (1.99 ~ 4.25) | 4.46 × 10-7 | |
AA | 52 (18.25) | 55 (9.65) | 3.89 (2.42 ~ 6.26) | 4.82 (2.84 ~ 8.17) | 1.21 × 10-6 | |
GA + AA | 226 (79.30) | 327 (57.37) | 2.85 (2.04 ~ 3.96) | 3.19 (2.21 ~ 4.61) | 2.16 × 10-8 | |
Test for trend | 2.08 (1.66 ~ 2.61) | 2.30 (1.79 ~ 2.97) | 3.17 × 10-8 | |||
CYP2C19*3 | ||||||
rs4986893 | GG | 262 (91.93) | 509 (89.30) | 1.00 (Reference) | 1.00 (Reference) | 0.236 |
GA | 23 (8.07) | 61 (10.70) | 0.73 (0.44 ~ 1.21) | 0.72 (0.422 ~ 1.24) | ||
EMs | *2/*2,*2/*3 | 226 (79.30) | 491 (86.14) | 1.00 (Reference) | 1.00 (Reference) | 0.009 |
PMs | *1/*1, *1/*2, *1/*3 | 59 (20.70) | 79 (13.86) | 1.62 (1.12 ~ 2.35) | 1.71 (1.14 ~ 2.57) |