The association of polymorphisms of TLR4 and CD14genes with susceptibility to sepsis in a Chinese population

BMC Medical Genetics

Table 4 The genotype and allele frequencies of patients with sepsis and controls

Polymorphism	Genotypes			χ2	P	Alleles		OR(95% CI)	P
Polymorphism	11	12	22	χ2	P	1	2	OR(95% CI)	P
TLR4
rs10759932(T/C)	TT	TC	CC			T	C
Controls	130	62	7	0.987	0.611	322	76	0.874(0.592-1.290)	0.499
Cases	106	40	6	0.987	0.611	252	52	0.874(0.592-1.290)	0.499
rs12377632(C/T)	CC	CT	TT			C	T
Controls	86	94	19	0.433	0.805	266	132	0.916(0.665-1.261)	0.591
Cases	71	67	14	0.433	0.805	209	95	0.916(0.665-1.261)	0.591
rs1927907(C/T)	CC	CT	TT			C	T
Controls	136	47	5	0.499	0.802	319	57	1.075(0.710-1.630)	0.732
Cases	109	37	6	0.499	0.802	255	49	1.075(0.710-1.630)	0.732
rs11536879(A/G)	AA	AG	GG			A	G
Controls	145	48	3	0.756	0.72	338	54	1.031(0.670-1.588)	0.889
Cases	110	41	1	0.756	0.72	261	43	1.031(0.670-1.588)	0.889
rs11536889(G/C)	GG	GC	CC			G	C
Controls	109	75	15	6.918	0.031	293	105	1.430(1.032-1.981)	0.031
Cases	62	77	13	6.918	0.031	201	103	1.430(1.032-1.981)	0.031
rs7873784(G/C)	GG	GC	CC			G	C
Controls	157	39	2	0.616	0.752	353	43	1.173(0.737-1.866)	0.501
Cases	116	34	2	0.616	0.752	266	38	1.173(0.737-1.866)	0.501
CD14
rs2569190(A/G)	AA	AG	GG			A	G
Controls	65	87	45	3.973	0.137	217	177	1.322(0.975-1.793)	0.073
Cases	58	72	22	3.973	0.137	188	116	1.322(0.975-1.793)	0.073
rs2563298(C/A)	CC	CA	AA			C	A
Controls	141	53	4	12.41	0.001	335	61	2.454(1.458-4.130)	0.001
Cases	132	19	1	12.41	0.001	283	21	2.454(1.458-4.130)	0.001

ISSN: 1471-2350