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Table 4 Relative risk A of lymphoma-specific death and lymphoma progression for selected SNPs previously associated with any follicular lymphoma outcome in at least one previous study

From: A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival

       

Lymphoma-specific death

ProgressionB

 

Chr

Gene

SNP

Position

A1

A2

MAF

HR (95% CI)A

p-value

HR (95% CI)A

p-value

1

CD46

rs2466571

206006669

A

C

0.49

0.98 (0.73; 1.32)

0.90

1.37 (1.10; 1.72)

0.006

1

CD55

rs2564978C

205561039

T

C

0.31

0.88 (0.62; 1.25)

0.47

1.13 (0.86; 1.49)

0.38

1

CFH

rs1065489

194976397

A

C

0.15

0.89 (0.57; 1.39)

0.60

0.92 (0.65; 1.31)

0.66

1

CFH

rs1329423C

194913010

C

T

0.22

0.94 (0.66; 1.39)

0.81

1.06 (0.79; 1.42)

0.71

1

CFH

rs3766404

194918455

G

A

0.16

1.14 (0.77; 1.68)

0.51

1.12 (0.80; 1.55)

0.52

1

CFHR5

rs6694672C

195212412

G

T

0.09

1.01 (0.61; 1.67)

0.97

1.02 (0.66; 1.57)

0.93

1

FCGR2A

rs1801274

159746369

A

G

0.47

0.76 (0.56; 1.03)

0.08

0.86 (0.68; 1.08)

0.19

1

MTHFR

rs1801131C

11777063

G

T

0.32

0.69 (0.49; 0.97)

0.03

0.59 (0.45; 0.77)

0.0001E

1

SELE

rs5361

167967684

C

A

0.11

1.04 (0.64; 1.69)

0.89

0.90 (0.61; 1.32)

0.59

2

IL1RN

rs454078C

113605264

T

A

0.28

0.99 (0.69; 1.42)

0.96

0.94 (0.72; 1.23)

0.66

3

FTHFD

rs1127717C

127308749

C

T

0.16

0.91 (0.58; 1.43)

0.69

0.98 (0.70; 1.38)

0.92

4

IL2

rs2069762C

123597430

C

A

0.26

0.63 (0.43; 0.92)

0.02

0.89 (0.69; 1.16)

0.38

4

IL8

rs4073C

74824888

A

T

0.46

0.93 (0.70; 1.25)

0.64

0.78 (0.62; 0.97)

0.02

4

IL8

rs2227307C

74825533

G

T

0.45

0.93 (0.69; 1.25)

0.63

0.75 (0.60; 0.94)

0.01

5

C9

rs1421094C

39391348

A

G

0.37

1.19 (0.88; 1.61)

0.27

1.00 (0.79; 1.27)

0.98

5

IL12B

rs3212227C

158675528

G

T

0.17

1.21 (0.81; 1.80)

0.36

1.42 (1.03; 1.94)

0.03

6

C6orf15

rs6457327D

31182009

A

C

0.42

0.90 (0.66; 1.24)

0.53

0.90 (0.71; 1.14)

0.38

6

IFNGR1

rs3799488

137561473

G

A

0.12

0.76 (0.46; 1.24)

0.27

1.12 (0.79; 1.57)

0.53

8

GGH

rs719235C

64114235

A

C

0.32

0.96 (0.69; 1.34)

0.82

1.00 (0.77; 1.29)

0.99

9

GALNT12

rs10819377

100643533

A

G

0.46

0.76 (0.56; 1.03)

0.07

0.89 (0.71; 1.12)

0.33

16

IL4R

rs1801275

27281901

G

A

0.25

0.91 (0.64; 1.30)

0.62

0.85 (0.65; 1.12)

0.26

22

MIF

rs755622C

22566392

C

G

0.16

0.76 (0.49; 1.16)

0.20

0.85 (0.61; 1.18)

0.34

  1. AEstimated with Hazard ratio, HR, and 95% confidence interval, CI. Adjusted for age at diagnosis, sex and three principal components.
  2. BSwedish cases only (n = 231) for time to progression.
  3. CImputed SNP.
  4. Drs6457327 has previously been associated with both FL risk and prognosis.
  5. EOpposite direction of association to previous study [15].
  6. The minor allele (A1) was investigated for association except for rs2466571 (CD46), where the major allele (A2) was used as reference for easier comparison with previous study result.
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BMC Medical Genetics

ISSN: 1471-2350

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