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Table 3 Clinical and immunological characterization and inferred haplotypes present in a sample of 10 Canadian HH patients

From: A new 500 kb haplotype associated with high CD8+ T-lymphocyte numbers predicts a less severe expression of hereditary hemochromatosis

   Age TfSat Ferritin TBIS Associated CD4+ CD8+ Haplotype 1 Haplotype 2
ID Gender (years) (%) (ng/ml) (g) diseases (×106/ml) ZSCAN12 PGBD1 ZNF193 ZNF165 ZNF184 ZSCAN12 PGBD1 ZNF193 ZNF165 ZNF184
1 M 52 96 2210 5.0   0.95 0.26 A A A T G A A A T G
2 M 54 97 1618 12.0   0.97 0.17 A A A T G A A A T G
3 F 65 95 1002 7.5   0.30 0.14 A A A T G A A A T G
4 F 63 n.a. 2550 28.5   0.66 0.21 A A A T G G A A T T
5 M 43 n.a. n.a. 25.0 Hepatitis C infection 0.80 0.43 A A A T G A A A T G
6 F 61 60 500 2.0 Celiac disease 0.93 0.53 A A A T G G A A T T
7 F 35 95 82 0.5 Hashimoto's thyroiditis 0.79 0.50 A A A T G A A A T G
8 M 51 83 646 2.6   0.55 0.43 A A A G T A A A T T
9 F 80 79 463 1.7 Small cell B lymphoma 0.64 0.40 G G G G G G A A T T
10 M 39 45 695 2.1   1.01 0.58 G G G G G G G G G T
  1. M: male; F: female. Tfsat: transferrin saturation. n.a.: not available.
  2. Alleles in bold represent conserved haplotype regions. Text in grey highlight subjects with associated diseases.