Skip to main content

Table 3 Association of SREBP-2 gene polymorphisms between the AVN subgroup patients and controls

From: Significant association of SREBP-2genetic polymorphisms with avascular necrosis in the Korean population

Loci

Sub-group

Genotype

 

Allele 2 vs. 1

Codominant Heterozy

Dominant

Recessive

  

11

12

22

MAF

  

(11 vs 12 vs 22)*

12 + 22 vs. 11

22 vs. 11 + 12

      

OR (95% CI)

P†

OR (95% CI)

P†

OR (95% CI)

P†

OR (95% CI)

P†

  

TT

CT

CC

         

IVS1+8408 T>C

Alc

74

102

30

0.393

0.764

(0.581–1.004)

0.054

0.759

(0.575–1.002)

0.052

0.744

(0.494–1.121)

0.157

0.629

(0.379–1.045)

0.073

(rs2267439)

Idio

69

85

27

0.384

0.701

(0.532–0.923)

0.011

0.695

(0.525–0.920)

0.011

0.625

(0.417–0.937)

0.023

0.617

(0.368–1.034)

0.067

 

Ster

16

31

9

0.438

0.865

(0.560–1.335)

0.511

0.860

(0.553–1.339)

0.504

0.940

(0.479–1.844)

0.857

0.677

(0.301–1.523)

0.346

  

GG

GT

TT

         

IVS3-342 G>T

Alc

115

74

16

0.259

1.017

(0.747–1.386)

0.914

1.016

(0.751–1.375)

0.916

1.021

(0.694–1.501)

0.917

1.022

(0.495–2.109)

0.954

(rs2269657)

Idio

94

73

14

0.279

1.159

(0.855–1.570)

0.342

1.165

(0.855–1.589)

0.333

1.153

(0.785–1.695)

0.468

1.431

(0.675–3.030)

0.350

 

Ster

32

20

2

0.222

0.951

(0.568–1.592)

0.848

0.949

(0.561–1.604)

0.845

0.989

(0.527–1.858)

0.973

0.704

(0.150–3.297)

0.656

  

GG

AG

AA

         

IVS11+414 G>A

Alc

95

84

25

0.328

1.241

(0.925–1.665)

0.150

1.244

(0.925–1.672)

0.149

1.143

(0.779–1.678)

0.493

2.037

(1.028–4.034)

0.041

(rs1052717)

Idio

85

72

24

0.332

1.214

(0.910–1.621)

0.188

1.214

(0.909–1.621)

0.189

1.092

(0.747–1.598)

0.649

1.998

(1.055–3.783)

0.034

 

Ster

22

30

4

0.339

1.230

(0.778–1.945)

0.376

1.258

(0.775–2.042)

0.352

1.452

(0.782–2.695)

0.237

0.966

(0.295–3.163)

0.954

  

GG

AG

AA

         

IVS12-1667 G>A

Alc

74

95

30

0.389

1.380

(1.036–1.837)

0.027

1.382

(1.036–1.844)

0.028

1.495

(1.007–2.220)

0.046

1.575

(0.877–2.828)

0.128

(rs2267443)

Idio

73

71

31

0.380

1.236

(0.930–1.642)

0.144

1.226

(0.927–1.620)

0.153

1.126

(0.759–1.669)

0.556

1.763

(1.015–3.059)

0.044

 

Ster

22

26

8

0.375

1.334

0.849–2.094)

0.211

1.340

(0.849–2.114)

0.209

1.408

(0.749–2.647)

0.288

0.566

(0.637–3.852)

0.328

  1. *11: homozygotes for the major allele, 12: heterozygotes and 22: homozygotes for the minor allele.
  2. † Logistic regression analyses were used for calculating. bold: P value < 0.05
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us