TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSBmutations in predicting diabetes

Table 2 Estimates of the genotype and allele relative risks for the TCF7L2 variants in the cases and controls based on ethnicity

	SNP*	Het OR (95% CI)	P	Hom OR (95% CI)	P	^&OR (95% CI)	P
All cases vs all controls	rs7903146	0.90 (0.70–1.15)	0.40	1.02 (0.67–1.55)	0.92	0.96 (0.80–1.16)	0.70
	rs12255372	1.03 (0.80–1.34)	0.80	0.88 (0.52–1.49)	0.62	0.98 (0.80–1.21)	0.88
DR cases vs DR controls	rs7903146	0.90 (0.64–1.27)	0.55	0.95 (0.54–1.68)	0.86	0.94 (0.73–1.21)	0.65
	rs12255372	0.92 (0.63–1.36)	0.69	1.41 (0.60–3.30)	0.42	1.04 (0.76–1.41)	0.81
IE cases vs IE controls	rs7903146	0.86 (0.57–1.30)	0.48	1.06 (0.54–2.08)	0.86	0.96 (0.71–1.29)	0.79
	rs12255372	0.99 (0.65–1.48)	0.95	0.96 (0.42–2.23)	0.93	0.98 (0.71–1.36)	0.92

SNP, single nucleotide polymorphism; *baseline genotype at rs7903146-CC, rs12255372-GG; Het OR & Hom OR, genotype relative risk (GRR) for heterozygotes and homozygotes respectively (GRR was calculated by comparing with the baseline genotype); ^&, allelic OR; P, P value; DR, Dravidians; IE, Indo-European

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