Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China

Table 2 Genotype frequencies and minor allele frequencies of genetic polymorphisms in ulcerative colitis patients and controls.

	Controls Frequencies (%)	UC patients Frequencies (%)	P-value	OR (95% CI)*
MTHFR 677
CC ^#	40.9	38.1
CT ^#	43.3	45.2	0.6053^a	1.12 (0.72–1.75)
TT	15.8	16.7	0.6821^a	1.13 (0.62–2.05)
Total number of patients analysed	215	168
Allele T	0.37	0.39	0.6027	1.09 (0.81–1.46)
*MTHFR 1298*
AA ^#	66.2	69.4
AC	29.1	28.1	0.7277^a	0.92 (0.58–1.46)
CC	4.7	2.5	0.2631^a	0.51 (0.15–1.66)
Total number of patients analysed	213	160
Allele C	0.19	0.17	0.3455	0.86 (0.59–1.26)
*MTR 2756*
AA ^#	83.5	73.7
AG	15.1	23.1	0.0422^a	1.72 (1.02–2.92)
GG	1.4	3.2	0.1899^a	2.64 (0.62–11.25)
Total number of patients analysed	218	156
Allele G	0.09	0.15	0.0137	1.81 (1.15–2.84)
*MTRR 66*
AA ^#	58.0	53.7
AG	35.6	38.4	0.4839^a	1.17 (0.76–1.79)
GG	6.4	7.9	0.4746^a	1.34 (0.60–2.99)
Total number of patients analysed	219	164
Allele G	0.24	0.27	0.2401	1.18 (0.85–1.64)
*TCN2 776*
CC ^#	21.8	18.5
CG	38.9	45.2	0.3358^a	1.26 (0.79–2.01)
GG	39.3	36.3	0.7835^a	1.09 (0.61–1.95)
Total number of patients analysed	216	146
Allele G	0.58	0.59	0.9447	1.0 (0.74–1.35)

*(OR: unadjusted odds ratio; 95 CI%: 95% confidence interval)
Abbreviations :methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methylenetetrahydrofolate reductase (MTRR) and transcobalamin (TCN2)
^# Dominant genotype. ^a Comparison with dominant genotype.

ISSN: 1471-2350