Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study

Table 1 Sample characteristics for the AFDS, FHS, and the HAPI Heart Study.

	AFDS	FHS	HAPI
N	1189	1759	851
Sex (% male)	45.3%	49.6%	53.2%
Mean (SD) age (yrs)	49.4 ± 17.1	59.4 ± 9.4	43.6 ± 13.9
Mean (SD) BMI (kg/m²)	27.2 ± 5.0	28.0 ± 5.1	26.7 ± 4.5
Hypertension medication use (%)	9.3%	29.6%	*
Mean (SD) SBP/DBP (mmHg)	122.2 ± 15.9	125.5 ± 17.4	116.5 ± 13.3
Those on medication removed	77.7 ± 9.6	74.8 ± 9.1	70.6 ± 7.5
Mean (SD) SBP/DBP (mmHg)	125.2 ± 18.9	132.4 ± 20.8	*
Constant added to those on medication	78.5 ± 10.2	77.0 ± 10.0

* Anti-hypertension medications were withdrawn 7 days prior to testing and therefore no HAPI subjects were on medications at the time of study.

ISSN: 1471-2350