Table 2 Distribution of genotypes of the -23HphI (A/T) insulin polymorphism in German patients with autoimmune endocrinopathies and healthy controls
Genotype | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
AA | AT | TT | Allele | ||||||||
Group | n | n | % | n | % | n | % | p* | A% | T% | p* |
HC | 275 | 144 | 52.4 | 118 | 42.9 | 13 | 4.7 | 73.8 | 26.2 | ||
T1D | 317 | 239 | 75.4 | 70 | 22.1 | 8 | 2.5 | 3.7 × 10-8 | 86.4 | 13.6 | 6.6 × 10-8 |
HT | 61 | 32 | 52.5 | 29 | 47.5 | 0 | 0 | 0.2092 | 76.2 | 23.8 | 0.6623 |
AD | 107 | 54 | 50.5 | 46 | 43.0 | 7 | 6.5 | 0.7641 | 72.0 | 28.0 | 0.6675 |
APS-II | 62 | 35 | 56.5 | 23 | 37.1 | 4 | 6.5 | 0.6485 | 75.0 | 25.0 | 0.8746 |
T1D + AIT | 22 | 16 | 72.7 | 5 | 22.7 | 1 | 4.5 | 0.1675 | 84.1 | 15.9 | 0.1848 |
T1D + HT | 15 | 11 | 73.3 | 3 | 20.0 | 1 | 6.7 | 0.2159 | 83.3 | 16.7 | 0.3436 |
T1D + GD | 7 | 5 | 71.4 | 2 | 28.6 | 0 | 0 | 0.5628 | 85.7 | 14.3 | 0.4873 |
AD + AIT | 33 | 17 | 51.5 | 13 | 39.4 | 3 | 9.1 | 0.5572 | 71.2 | 28.8 | 0.7597 |
AD + HT | 23 | 13 | 56.5 | 8 | 34.8 | 2 | 8.7 | 0.5870 | 73.9 | 26.1 | 0.8724 |
AD + GD | 10 | 4 | 40.0 | 5 | 50.0 | 1 | 10 | 0.6242 | 65 | 35 | 0.5353 |
T1D + AD + HT | 7 | 2 | 28.6 | 5 | 71.4 | 0 | 0.3087 | 64.3 | 73.8 | 0.6227 | |