BMC Medical Genetics

Table 5 Effect of design and population parameters or non-centrality parameters

From: Design considerations in a sib-pair study of linkage for susceptibility loci in cancer

	Simulated Range	Z_c/√F		Z_p/√F
		Estimate	SE^a	Estimate	SE
(Intercept)		-0.3392	0.0064	-0.2941	0.0085
Recombination Fraction	0.025–0.25	-0.5783	0.0247	-0.5757	0.0228
Total Affected Sibs	2–3	0.0948	0.0020	0.1088	0.0026
Affected Sibs Typed	2–3	0.1111	0.0022	0.0670	0.0029
Total Unaffected Sibs^b	0–3	0.0003	0.0011	0.0043	0.0021
Parents Typed	0–2	0.0156	0.0009	0.0099	0.0012
Spouse-Offspring Proxy	0–1^c	-0.0222	0.0028	-0.0179	0.0041
Spouse-2 Offspring Proxy	0–1 ^c	-0.0050	0.0027	-0.0050	0.0038
AR Linked Locus	0.025–0.12	1.5785	0.0360	1.5154	0.0402
AR Unlinked Locus	0.0–0.12	-0.9867	0.0252	-0.7830	0.0295
Screen for Unlinked (AR1 > AR2)	0–1 ^c	-0.0016	0.0057	0.0054	0.0053
Screen for Unlinked (AR1 ≤ AR2)	0–1 ^c	0.0666	0.0042	0.0661	0.0040

Multiple linear regression of Z/ $\sqrt{F}$ on simulation parameters.
^aStandard error of Estimate; ^bNumber available for Z _c, number genotyped for Z _p; ^cIndicator variable.

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ISSN: 1471-2350

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