Skip to main content

Table 5 Effect of design and population parameters or non-centrality parameters

From: Design considerations in a sib-pair study of linkage for susceptibility loci in cancer

  Simulated Range Z c /√F Z p /√F
   Estimate SEa Estimate SE
(Intercept)   -0.3392 0.0064 -0.2941 0.0085
Recombination Fraction 0.025–0.25 -0.5783 0.0247 -0.5757 0.0228
Total Affected Sibs 2–3 0.0948 0.0020 0.1088 0.0026
Affected Sibs Typed 2–3 0.1111 0.0022 0.0670 0.0029
Total Unaffected Sibsb 0–3 0.0003 0.0011 0.0043 0.0021
Parents Typed 0–2 0.0156 0.0009 0.0099 0.0012
Spouse-Offspring Proxy 0–1c -0.0222 0.0028 -0.0179 0.0041
Spouse-2 Offspring Proxy 0–1 c -0.0050 0.0027 -0.0050 0.0038
AR Linked Locus 0.025–0.12 1.5785 0.0360 1.5154 0.0402
AR Unlinked Locus 0.0–0.12 -0.9867 0.0252 -0.7830 0.0295
Screen for Unlinked (AR1 > AR2) 0–1 c -0.0016 0.0057 0.0054 0.0053
Screen for Unlinked (AR1 ≤ AR2) 0–1 c 0.0666 0.0042 0.0661 0.0040
  1. Multiple linear regression of Z/ F MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaWaaOaaaeaacqWGgbGraSqabaaaaa@2D05@ on simulation parameters.
  2. aStandard error of Estimate; bNumber available for Z c , number genotyped for Z p ; cIndicator variable.