Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTOvariants confer a significant risk

Table 3 SNPs with significant association to quantitative phenotypes of T2D

Gene/SNP	Risk Allele	Trait associated with T2D	R-Square	p (adjusted)
NGT Subjects^¥
*CDK5*	C	HDL-cholesterol ↓ Φ	0.021	0.005
rs 7754840
TCF7L2	C	Total-cholesterol ↑	0.004	0.083
rs 10885409		LDL-cholesterol↑	0.016	0.010
Combined**
NGT, T2D
*CDK5*	C	HDL-cholesterol ↓	0.021	0.005
rs 7754840
*TCF7L2*	C	Total-cholesterol↑	0.009	0.008
rs 10885409		LDL-cholesterol↑	0.012	0.003

^¥ Multiple linear regression analyses were adjusted for age, sex, BMI, and medication; **Multiple linear regression analyses were adjusted for age, sex, BMI, disease status, and medication; Φ Arrows indicate risk-allele associated increase or decrease in quantitative trait.

ISSN: 1471-2350