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Table 3 SNPs with significant association to quantitative phenotypes of T2D

From: Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTOvariants confer a significant risk

Gene/SNP Risk Allele Trait associated with T2D R-Square p (adjusted)
NGT Subjects¥     
CDK5 C HDL-cholesterol ↓ Φ 0.021 0.005
rs 7754840     
TCF7L2 C Total-cholesterol ↑ 0.004 0.083
rs 10885409   LDL-cholesterol↑ 0.016 0.010
Combined**     
NGT, T2D     
CDK5 C HDL-cholesterol ↓ 0.021 0.005
rs 7754840     
TCF7L2 C Total-cholesterol↑ 0.009 0.008
rs 10885409   LDL-cholesterol↑ 0.012 0.003
  1. ¥ Multiple linear regression analyses were adjusted for age, sex, BMI, and medication; **Multiple linear regression analyses were adjusted for age, sex, BMI, disease status, and medication; Φ Arrows indicate risk-allele associated increase or decrease in quantitative trait.