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Table 4 Results of mitochondrial SNP association testing with ischemic stroke risk. Significant uncorrected P-values (< 0.05) are highlighted in bold. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) are shown only for significantly associated polymorphisms.

From: Mitochondrial haplogroup H1 is protective for ischemic stroke in Portuguese patients

  Number of Individuals (%) Chi-square Test Logistic Regression Model
SNPs* Controls Patients P-value OR [95% CI] P-value OR [95% CI]
m.709G>A 91 (18.3) 101 (19.1) 0.760   0.113  
m.1719G>A 21 (4.3) 31 (5.9) 0.239   0.942  
m.3010G>A 156 (31.3) 123 (23.0) 0.003 0.66 [0.50–0.87] 0.016 0.63 [0.43–0.92]
m.3348A>G 15 (3.0) 11 (2.1) 0.329   0.794  
m.4580G>A 13 (2.6) 12 (2.2) 0.704   0.860  
m.5999T>C 13 (2.6) 17 (3.2) 0.596   0.293  
m.7028C>T 248 (50.5) 307 (59.7) 0.003 1.45 [1.13–1.87] 0.005 1.63 [1.16–2.29]
m.7805G>A 11 (2.2) 12 (2.3) 0.960   0.656  
m.8251G>A 23 (4.6) 28 (5.3) 0.620   0.706  
m.8701A>G 33 (6.7) 41 (7.7) 0.530   0.714  
m.9055G>A 30 (6.0) 34 (6.4) 0.820   0.464  
m.10398A>G 97 (19.5) 111 (20.9) 0.591   0.178  
m.10873T>C 30 (6.4) 39 (7.5) 0.519   0.771  
m.11719G>A 235 (47.1) 289 (54.1) 0.024 1.33 [1.04–1.69] 0.037 1.43 [1.02–1.99]
m.12308A>G 92 (18.5) 114 (21.4) 0.255   0.118  
m.12705C>T 53 (11.6) 73 (14.5) 0.186   0.683  
m.13368G>A 57 (11.6) 66 (12.5) 0.679   0.337  
m.13617T>C 24 (4.8) 34 (6.3) 0.278   0.047 2.18 [1.01–4.70]
m.13708G>A 45 (9.0) 47 (8.9) 0.925   0.209  
  1. *As an example, m.709G>A stands for a G to A transition at mtDNA nucleotide position 709. The number of individuals and test statistics refer to the derived (second) allele (A in this example).