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Table 4 The p-values of marginal Fisher's exact tests between groups

From: The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population

Id

Variant

Sporadic-Sub-cohort

Familiar-Sub-cohort

Sporadic-familiar

All

 

MLH1

    

23

c.307-29 C>A

0.7259

1.0000

0.6673

0.8632

25

c.453+79 A>G

0.7908

-

-

-

24

c.350 C>T

-

0.2988

-

-

26

c.545+43 C>G

0.3263

1.000

1.000

0.4741

27

c.655 A>G

0.7715

0.5619

0.4869

0.7489

28

c.790+10 A>G

1.0000

-

-

-

29

C884+39G>A

-

0.2943

-

-

85

c.1217 G>A

1.0000

0.5359

0.4858

0.4833

31

c.1379 A>C

-

0.1880

-

-

32

c.1558+14 G>A

1.0000

0.6063

0.7685

0.8722

37

c.1668-19 A>G

0.5382

0.0044

0.0329

0.0148

33

c.1732-2 A>T

-

0.3109

-

-

34

c.1852_1853 AA>GC

0.2408

0.5672

0.6760

0.3569

100

c.1942 C>T

-

0.4747

  

35

c.1959 G>T

0.2473

1.0000

0.3642

0.4493

36

c.2152 C>T

-

0.0840

-

-

 

MSH2

    

89

c.-118 T>C

0.0037

-

-

-

41

c.965 G>A

0.2574

0.0244

0.3609

0.0582

43

c.1511-9 A>T

0.0958

0.7314

0.0796

0.1617

  1. The Bonferroni corrected p-value of sporadic versus sub-cohort is 0.05/13 = 0.0038
  2. The Bonferroni corrected p-value of familiar-versus sub-cohort is 0.05/15 = 0.0033
  3. Polymorphic variants with borderline significant p-values are in bold
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BMC Medical Genetics

ISSN: 1471-2350

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