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Table 3 Type 2 diabetes case-control study by obesity status

From: The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

Functional relevance

Gene name

SNP rs ID

Genetic model

Obesity status

OR [95%CI]

P value

Woolf test

Risk allele frequency

        

T2D

NG

Insulin action

ADIPOQ

rs17300539

Dominant

Non-obese

0.96 [0.77–1.20]

0.71

0.5

0.09

0.10

    

Obese

1.07 [0.84–1.35]

0.58

 

0.10

0.09

    

All together

0.99 [0.86–1.15]

0.91

 

0.10

0.09

 

ADIPOQ

rs266729

Dominant

Non-obese

1.00 [0.85–1.19]

0.97

0.07

0.26

0.26

    

Obese

1.25 [1.04–1.49]

0.015

 

0.25

0.24

    

All together

1.08 [0.96–1.21]

0.18

 

0.25

0.25

 

ENPP1

rs1044498

Additive

Non-obese

0.99 [0.84–1.17]

0.94

0.02

0.15

0.15

    

Obese

1.30 [1.10–1.54]

0.003

 

0.17

0.14

    

All together

1.15 [1.03–1.28]

0.014

 

0.16

0.15

 

PPARG

rs1801282

Recessive

Non-obese

0.85 [0.69–1.05]

0.136

0.24

0.91

0.89

    

Obese

0.73 [0.58–0.90]

0.004

 

0.90

0.87

    

All together

0.81 [0.71–0.94]

0.004

 

0.90

0.89

 

RETN

rs1862513

Recessive

Non-obese

0.81 [0.60–1.09]

0.16

0.11

0.30

0.30

    

Obese

1.14 [0.84–1.55]

0.42

 

0.30

0.31

    

All together

1.00 [0.82–1.22]

0.99

 

0.30

0.30

Beta-cell defect

GCK

rs1799884

Additive

Non-obese

1.23 [1.06–1.45]

0.009

0.55

0.20

0.17

    

Obese

1.15 [0.97–1.35]

0.12

 

0.19

0.18

    

All together

1.20 [1.08–1.34]

0.001

 

0.19

0.18

 

HNF1A

rs1169288

Additive

Non-obese

1.14 [1.01–1.30]

0.042

0.06

0.34

0.32

    

Obese

0.96 [0.84–1.10]

0.53

 

0.32

0.34

    

All together

1.02 [0.93–1.11]

0.71

 

0.33

0.32

 

HNF4A

rs1884614

Additive

Non-obese

1.06 [0.90–1.24]

0.51

0.94

0.17

0.17

    

Obese

1.05 [0.89–1.25]

0.54

 

0.17

0.17

    

All together

1.03 [0.93–1.15]

0.58

 

0.17

0.17

 

HNF4A

rs2144908

Additive

Non-obese

1.08 [0.92–1.27]

0.33

0.75

0.18

0.17

    

Obese

1.04 [0.88–1.24]

0.63

 

0.17

0.17

    

All together

1.04 [0.94–1.16]

0.45

 

0.17

0.17

 

KCNJ11

rs5219

Dominant

Non-obese

0.93 [0.78–1.10]

0.38

0.8

0.37

0.38

    

Obese

0.96 [0.80–1.15]

0.68

 

0.37

0.37

    

All together

0.90 [0.80–1.01]

0.085

 

0.37

0.38

 

SLC30A8

rs13266634

Additive

Non-obese

0.87 [0.76–0.99]

0.043

0.37

0.73

0.70

    

Obese

0.95 [0.82–1.09]

0.44

 

0.73

0.71

    

All together

0.91 [0.83–0.99]

0.033

 

0.73

0.70

 

TCF7L2

rs7903146

Additive

Non-obese

1.89 [1.67–2.14]

4.5 × 10 -23

3.2 × 10 -5

0.45

0.30

    

Obese

1.30 [1.14–1.48]

1.1 × 10 -4

 

0.36

0.30

    

All together

1.59 [1.46–1.73]

7.9 × 10 -27

 

0.40

0.30

  1. Odds ratios were adjusted for age, gender and BMI
  2. Woolf test: Test for heterogeneity in genotypic distribution between obese and non-obese subjects
  3. Non-obese: BMI < 30 kg/m2
  4. Obese: BMI ≥ 30 kg/m2
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BMC Medical Genetics

ISSN: 1471-2350

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