Table 2 Reported alterations in expression pattern, linked markers and the number of 185 SNPs tested for each of the 10 candidate genes
# | Gene name | Symbol | Chr | SNP1 | Altered expressional2 | Linked marker(s)3 | pmid |
|---|---|---|---|---|---|---|---|
mRNA | |||||||
1. | Enolase 2 (gamma, neuronal) | ENO2 | 12p13 | 4 | Prefrontal cortex (↑) | 15474909 | |
2. | Glycogen synthase kinase 3 beta | GSK3B | 3q13.3 | 34 | Hippocampus (↓) | 12363385 | |
3. | Mitogen-activated protein kinase 14 | MAPK14 | 6p21 | 40 | Dorsolateral prefrontal cortex (↓) | 12363385, 15098003 | |
4. | Phosphoglycerate mutase 1 (brain) | PGAM1 | 10q25.3 | 11 | Prefrontal cortex (↓) | 11576761 | |
PROTEIN | |||||||
5. | Enolase 1, (alpha) | ENO1 | 1p36.2 | 5 | Prefrontal cortex (↓) | 15098003 | |
1. | Enolase 2 (gamma, neuronal) | ENO2 | 12p13 | - | Prefrontal cortex (↓) | 15098003 | |
6. | Glyceraldehyde-3-phosphate dehydrogenase | GAPDH | 12p13 | 3 | Prefrontal cortex (↓) | 15098003 | |
2. | Glycogen synthase kinase 3 beta | GSK3B | 3q13.3 | - | Prefrontal cortex (↓), frontal cortex (↓) | 15098003, 11290401 | |
7. | Hexokinase 1 | HK1 | 10q22 | 32 | Prefrontal cortex (↑, ↓) | 10784483, 15098003 | |
4. | Phosphoglycerate mutase 1 (brain) | PGAM1 | 10q25.3 | - | Prefrontal cortex (↓) | 15098003 | |
LINKAGE | |||||||
4. | Phosphoglycerate mutase 1 (brain) | PGAM1 | 10q25.3 | - | D10S677 | 9754621 | |
8. | Phosphoenolpyruvate carboxykinase 2 | PCK2 | 14q31.1 | 4 | D14S70 | 12808429 | |
9. | Phosphoenolpyruvate carboxykinase 1 | PCK1 | 20q13.31 | 8 | D20S100 | 11803533 | |
10. | Fructose-1,6-bisphosphatase 1 | FBP1 | 9q21.33 | 15 | D9S1812 | 12808429 | |
3. | Mitogen-activated protein kinase 14 | MAPK14 | 6p21 | - | D6S1610, D6S271, | 12929083,11126394, | |
D6S291, HLADQA, | 12140777,7581457 | ||||||
HLADQB, HLA-DQB1, | |||||||
HLADRB1, D6S273, | |||||||
HLAA, D6S464 |