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Figure 4 | BMC Medical Genetics

Figure 4

From: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ε4 allele

Figure 4

lhcgr2 shares similarity with consensus 3' acceptor splice sites and ApoE mRNA. (A) lhcgr2 as a potential miRNA that regulates the expression of ApoE. The reversed LHCGR sequence is complimentary to a fragment of APOE mRNA at 13 out of 16 sites. (B) Pairwise sequence alignment of a portion of LHR intron 1 in human and mouse (Mus musculus). The human sequence includes lhr2 (rs4073366) and bears sequence features characteristic of 3' acceptor splice sites.

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BMC Medical Genetics

ISSN: 1471-2350

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