lhcgr2 shares similarity with consensus 3' acceptor splice sites and ApoE mRNA. (A) lhcgr2 as a potential miRNA that regulates the expression of ApoE. The reversed LHCGR sequence is complimentary to a fragment of APOE mRNA at 13 out of 16 sites. (B) Pairwise sequence alignment of a portion of LHR intron 1 in human and mouse (Mus musculus). The human sequence includes lhr2 (rs4073366) and bears sequence features characteristic of 3' acceptor splice sites.